Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Department of Statistics and Actuarial Science, Soongsil University, Seoul, South Korea.
J Psychiatr Res. 2023 Nov;167:93-99. doi: 10.1016/j.jpsychires.2023.10.022. Epub 2023 Oct 15.
Regular physical activity (PA) has been suggested as effective disease preventable strategies for Parkinson's disease (PD). Depression often precedes PD but whether PA also would reduce the risk of PD in patients with depression has not been known. The aim of study is to examine the association of regular PA with risk of PD among patients with depressive disorder. A total of 1,342,282 patients with depressive disorder were identified from a nationwide health screening cohort from 2010 to 2016. The exposure was changes in pattern of regular PA between pre-and post-diagnosis of depressive disorder, categorized as four groups; 1) no PA, 2) increased PA, 3) decreased PA, and 4) maintaining PA. The outcome was risk of incident PD, calculated using multivariate adjusted Cox proportional hazards regressions according to the PA categorization. Total of 8901 PD cases (0.66%) were developed during 5.3 years of follow-up period. Maintaining PA group was associated with the lowest risk of PD (adjusted hazard ratio [aHR] 0.89, 95% CI 0.83-0.97) among all other PA groups with depressive disorder (with no PA group as reference). Otherwise, decreased PA group significantly increased the risk of PD (aHR 1.10, 95% CI 1.03-1.16). Those who maintained PA before and after diagnosis of depressive disorder were associated with lower risk of incident PD.
定期进行身体活动（PA）已被认为是预防帕金森病（PD）的有效疾病策略。抑郁症通常先于 PD 发生，但定期进行 PA 是否也会降低抑郁患者患 PD 的风险尚不清楚。本研究旨在探讨定期进行 PA 与抑郁患者 PD 风险之间的关联。
从 2010 年至 2016 年，一项全国性健康筛查队列中确定了 1342282 名患有抑郁障碍的患者。暴露因素是抑郁障碍诊断前后定期进行 PA 的模式变化，分为 4 组：1）无 PA，2）增加 PA，3）减少 PA 和 4）维持 PA。根据 PA 分类，使用多变量调整 Cox 比例风险回归计算了 PD 发病风险的结局。在 5.3 年的随访期间，共发生 8901 例 PD（0.66%）。与其他所有患有抑郁障碍的 PA 组（以无 PA 组为参照）相比，维持 PA 组的 PD 风险最低（调整后的危险比[aHR]0.89，95%CI 0.83-0.97）。相反，减少 PA 组显著增加了 PD 的风险（aHR 1.10，95%CI 1.03-1.16）。在抑郁障碍诊断前后维持 PA 的患者发生 PD 的风险较低。
