Turakulov Ia Kh, Tashkhodzhaeva T P, Burikhanov R B, Ismailov S I, Shakhizirov D Sh
Probl Endokrinol (Mosk). 1986 Sep-Oct;32(5):72-6.
Intrathyroid transformation of thyroxin (T4) into triiodothyronine (T3) and the role of thyrotropic hormone and denervation in this process were studied with in vivo blood perfusion of dog thyroid gland in situ and at 37 degrees C. Both labelled 125I-T4 (200,000 imp/min) and nonlabeled T4 (1000 ng) were administrated in the arteries of thyroid lobules in situ and in a constant-temperature cabinet. Enhanced excretion of triiodothyronine (both labeled and nonlabeled) observed two hours after the injection in the thyroid blood output was suggested as an evidence of denervation-independent deiodination occurring in the thyroid tissue. Without T4 load the proportion of T3 in the thyroid venous blood was significantly increasing under the thyroid denervation thus attesting inhibitory effect of nervous impulse on T4 deiodination in the thyroid gland. TTH being administrated into thyroid arteries in a dose of 20 I.U. produced a pronounced elevation of T4 thyroid conversion in T3 which was less manifest in the process of denervation thus evidencing the high sensitivity of the process to TTH.
在37℃条件下，通过对犬甲状腺进行原位活体血液灌注，研究了甲状腺内甲状腺素（T4）向三碘甲状腺原氨酸（T3）的转化过程以及促甲状腺激素和去神经支配在此过程中的作用。将标记的125I-T4（200,000脉冲/分钟）和未标记的T4（1000纳克）注入甲状腺小叶动脉，实验在原位及恒温箱中进行。注射后两小时，甲状腺血液输出中观察到三碘甲状腺原氨酸（标记和未标记的）排泄增加，这被认为是甲状腺组织中发生去神经支配非依赖性脱碘的证据。在无T4负荷的情况下，甲状腺去神经支配后甲状腺静脉血中T3的比例显著增加，从而证明神经冲动对甲状腺内T4脱碘具有抑制作用。以20国际单位的剂量将促甲状腺激素注入甲状腺动脉，可使T4向T3的甲状腺转化率显著升高，而去神经支配过程中这种升高不太明显，这证明该过程对促甲状腺激素高度敏感。
