HER Team and Department of Maternal and Child Health, Xiangya School of Public Health, Central South University, Hunan 410078, China.
HER Team and Department of Maternal and Child Health, Xiangya School of Public Health, Central South University, Hunan 410078, China; Institute of Applied Health Research, University of Birmingham, B15 2TT Birmingham, UK; Department of Psychiatry, University of Rochester, Rochester, NY, USA.
J Affect Disord. 2024 Jan 15;345:18-23. doi: 10.1016/j.jad.2023.10.103. Epub 2023 Oct 19.
To investigate the relationship between depression in early pregnancy and sleep quality in mid-pregnancy, and explore whether sleep disorders independently predicts depression across the perinatal period within women with or without depression in early pregnancy.
Data were collected at 7 time points from 12 weeks of pregnancy to 6 weeks postpartum. Multiple logistic regression and survival analysis were used to explore the relationship between sleep quality in mid-pregnancy and perinatal depression within women with or without depression in early pregnancy.
390 women were included. Women with depression in early pregnancy were more likely to have sleep disorders and perinatal depression. Women with sleep disorders had a higher risk of perinatal depression compared to women without sleep disorders in mid-pregnancy. Stratified analysis based on whether depressed at 12 weeks of pregnancy found that among women without depression, those with sleep disorders in mid-pregnancy were more likely to have subsequent perinatal depression and appeared earlier; whereas, among women with depression, mid-pregnancy sleep disorders was not a predictor of subsequent perinatal depression.
High rates of missed visits may lead to sample bias, with depression and sleep quality being assessed by self-report.
Women with depression in early pregnancy are more likely to have sleep disorders in mid-pregnancy. There is a strong correlation between sleep quality in mid-pregnancy and perinatal depression among women without depression in early pregnancy. Routine screening and intervention for sleep disorders should be a priority in perinatal care to reduce the incidence of perinatal depression.
本研究旨在探讨孕早期抑郁与孕中期睡眠质量的关系，并探讨睡眠障碍是否独立预测孕早期抑郁的女性在围产期内的抑郁情况。
本研究共收集了 12 周妊娠至产后 6 周的 7 个时间点的数据。采用多因素逻辑回归和生存分析方法，探讨孕中期睡眠质量与孕早期抑郁的女性在围产期内抑郁的关系。
共纳入 390 名女性。孕早期抑郁的女性更容易出现睡眠障碍和围产期抑郁。与孕中期无睡眠障碍的女性相比，睡眠障碍的女性发生围产期抑郁的风险更高。基于是否在 12 周妊娠时抑郁进行分层分析发现，在无抑郁的女性中，孕中期睡眠障碍的女性更有可能发生后续的围产期抑郁，且出现更早；而在抑郁的女性中，孕中期睡眠障碍并不是后续围产期抑郁的预测因素。
高比例的失访可能导致样本偏倚，抑郁和睡眠质量均通过自我报告评估。
孕早期抑郁的女性更有可能在孕中期出现睡眠障碍。对于孕早期无抑郁的女性，孕中期睡眠质量与围产期抑郁之间存在较强的相关性。在围产期护理中，常规筛查和干预睡眠障碍应作为预防围产期抑郁的重点。
