Student Research Committee, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Pharmacol Res. 2023 Nov;197:106963. doi: 10.1016/j.phrs.2023.106963. Epub 2023 Oct 18.
Long-chain n-3 poly unsaturated fatty acids have anti-inflammatory effects but their effects on serum levels of adhesion molecules are inconsistent and contradictory. In this updated systematic review and meta-analysis, marine sources of omega-3 fatty acids were pooled up to determine the effects of omega-3 supplementation on adhesion molecules. PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases (from inception to April 2023) were searched and all RCTs investigating the effects of marine sources of omega-3, on blood concentrations of adhesion molecules were included and a meta-analysis undertaken. Forty-two RCTs were included involving 3555 participants aged from 18 to 75 years. Meta-analysis of 38 arms from 30 RCTs reporting serum concentrations of vascular cell adhesion molecule-1 (VCAM-1) showed a significant reduction after omega-3 supplementation (WMD: -1.26, 95% CI: -1.88 to -0.64 ng/mL, P < 0.001). Meta-analysis of 40 arms from 30 RCTs reporting serum concentrations of intercellular adhesion molecule-1 (ICAM-1) revealed a reduction following omega-3 supplementation, although it was not significant (WMD: -1.76, 95%CI: -3.68 to 0.16 ng/mL, P = 0.07). Meta-analysis of 27 arms from 21 trials showed no effect on E-selectin (WMD: 0.01, 95%CI: -0.02 to 0.04 ng/mL, P = 0.62). Pooling 15 arms from 11 RCTs showed a marginally significant reducing effect on P-selectin concentrations (WMD: -2.67, 95%CI: -5.53 to 0.19 ng/mL, P = 0.06). A considerable decrease in VCAM concentration was observed after omega-3 supplementation in this meta-analysis with a trend to decreases in both ICAM and P-selectin levels, with effects that may be significant depending on study design, and there was no effect on E-selectin.
长链 n-3 多不饱和脂肪酸具有抗炎作用，但它们对黏附分子血清水平的影响不一致且相互矛盾。在本次更新的系统评价和荟萃分析中，汇集了海洋来源的 ω-3 脂肪酸，以确定 ω-3 补充剂对黏附分子的影响。检索了 PubMed-Medline、SCOPUS、Web of Science 和 Google Scholar 数据库（从创建到 2023 年 4 月），纳入了所有调查海洋来源 ω-3 对血液黏附分子浓度影响的随机对照试验，并进行了荟萃分析。共纳入 42 项 RCT，涉及 18 至 75 岁的 3555 名参与者。对 30 项 RCT 中 38 个臂的荟萃分析显示，血管细胞黏附分子-1（VCAM-1）血清浓度在 ω-3 补充后显著降低（WMD：-1.26，95%CI：-1.88 至-0.64 ng/mL，P < 0.001）。对 30 项 RCT 中 40 个臂的荟萃分析显示，细胞间黏附分子-1（ICAM-1）血清浓度在 ω-3 补充后降低，但无统计学意义（WMD：-1.76，95%CI：-3.68 至 0.16 ng/mL，P = 0.07）。对 21 项试验的 27 个臂的荟萃分析显示，E-选择素无影响（WMD：0.01，95%CI：-0.02 至 0.04 ng/mL，P = 0.62）。对 11 项 RCT 的 15 个臂的汇总分析显示，P-选择素浓度呈显著降低趋势（WMD：-2.67，95%CI：-5.53 至 0.19 ng/mL，P = 0.06）。荟萃分析显示，ω-3 补充后 VCAM 浓度显著降低，ICAM 和 P-选择素水平呈下降趋势，这些效果可能取决于研究设计，具有统计学意义，E-选择素无影响。
