Department of Pathology, University of Michigan, NCRC Building 35, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Surg Pathol Clin. 2023 Dec;16(4):779-804. doi: 10.1016/j.path.2023.05.011. Epub 2023 Jun 20.
Infectious diseases of the GI tract mimic a variety of other GI diseases, including chronic idiopathic inflammatory bowel disease and ischemia. It can be challenging to identify pathogens in tissue sections as well, as many trainees are not exposed to infectious disease pathology other than in the context of microbiology. Our ability to diagnose infections in formalin fixed, paraffin embedded material has grown exponentially with the advent of new histochemical and immunohistochemical stains, as well as more options for molecular testing. Correlating these diagnostic techniques with morphology has led to increasing understanding of the histologic patterns that are associated with specific pathogens.
胃肠道传染病类似于多种其他胃肠道疾病，包括慢性特发性炎症性肠病和缺血。在组织切片中识别病原体也具有挑战性，因为许多受训者除了在微生物学背景下，很少接触传染病病理学。随着新的组织化学和免疫组织化学染色以及更多分子检测选择的出现，我们在福尔马林固定、石蜡包埋材料中诊断感染的能力呈指数级增长。将这些诊断技术与形态学相关联，导致对与特定病原体相关的组织学模式的理解不断增加。
