最新模型已经到货！PLA2R1 相关膜性肾病的新型实验性小鼠模型。

The latest model has just arrived! A new experimental mouse model of PLA2R1-associated membranous nephropathy.

机构信息

Nephrology Section, Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts, USA.

出版信息

Kidney Int. 2023 Nov;104(5):878-880. doi: 10.1016/j.kint.2023.09.003.

DOI:10.1016/j.kint.2023.09.003

PMID:37863634

Abstract

Much akin to the explosion in number of known target antigens in membranous nephropathy, there has been a rapid expansion in the availability of animal models involving the first 2 antigens discovered in adult disease, phospholipase A2 receptor and thrombospondin type 1 domain-containing 7A. In this issue, Tomas et al. describe a novel mouse model of phospholipase A2 receptor-associated membranous nephropathy that shows great promise for investigating molecular mechanisms of disease and as an experimental system for testing existing and emerging therapies.

摘要

类似于膜性肾病中已知靶抗原数量的爆炸式增长，涉及到在成人疾病中发现的前 2 种抗原（即磷脂酶 A2 受体和血栓反应蛋白 1 型结构域 7A）的动物模型的可用性也迅速增加。在本期中，Tomas 等人描述了一种新型的磷脂酶 A2 受体相关膜性肾病的小鼠模型，该模型在研究疾病的分子机制以及作为测试现有和新兴疗法的实验系统方面具有很大的潜力。