基质金属蛋白酶 10 与腹膜衰竭的缓慢进程。

Matrix metalloproteinase 10 and the slow demise of the peritoneal membrane.

机构信息

Division of Nephrology, St. Joseph's Healthcare, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

出版信息

Kidney Int. 2023 Nov;104(5):880-882. doi: 10.1016/j.kint.2023.09.009.

DOI:10.1016/j.kint.2023.09.009

PMID:37863635

Abstract

Matrix metalloproteinases (MMPs) cleave matrix components along with multiple other effects. They are integral to virtually all biological processes, including inflammation and wound healing. As such, MMPs have been studied in the context of peritoneal membrane injury. MMP10 is a stromelysin and is involved in the degradation of matrix proteoglycans. Ishimura et al. demonstrate that MMP10 is involved in peritoneal membrane fibrosis. The clinical implications of these observations are presently unknown.

摘要

基质金属蛋白酶（MMPs）除了具有多种其他作用外，还能切割基质成分。它们几乎参与所有的生物学过程，包括炎症和伤口愈合。因此，人们已经在腹膜损伤的背景下对 MMPs 进行了研究。MMP10 是一种基质溶解素，参与基质蛋白聚糖的降解。Ishimura 等人证明 MMP10 参与腹膜纤维化。目前尚不清楚这些观察结果的临床意义。