Feklistov Andrey
Department of Structural Biology, Stanford School of Medicine, Stanford, CA 94305, USA.
Trends Biochem Sci. 2024 Jan;49(1):8-11. doi: 10.1016/j.tibs.2023.09.010. Epub 2023 Oct 18.
Despite significant progress in our understanding of promoter melting dynamics, underlying principles of the process remain elusive, with opposing views on key aspects held by many in the field. Here, I discuss the mechanistic logic behind the interplay of thermal and deterministic forces acting to create transcriptionally competent promoter complexes.
尽管我们对启动子解链动力学的理解取得了重大进展，但该过程的基本原理仍然难以捉摸，该领域的许多人对关键方面持有相反的观点。在这里，我将讨论热动力和确定性力相互作用背后的机制逻辑，这些力作用于形成具有转录活性的启动子复合物。
