具有潜在抗菌和抗肿瘤活性的新型苯并咪唑类化合物。
Novel benzimidazoles with potential antimicrobial and antineoplastic activities.
作者信息
Rida S M, Soliman F S, Badawy E S
出版信息
Pharmazie. 1986 Aug;41(8):563-5.
PMID:3786375
Abstract
The synthesis of some substituted 4-[1-(1-(1H-benzimidazol-2-yl) alkylamino]-1,5-dihydro-2H-pyrrol-2-ones and 3-[1-(1H-benzimidazol-2-yl)alkyl]-2-substituted-4(3H)-quinazolinon es is described. Five compounds displayed in vitro antibacterial and antifungal activities. Three of these compounds were tested against P-388 lymphocytic leukemia in mice and were inactive.
摘要
描述了一些取代的4-[1-(1-(1H-苯并咪唑-2-基)烷基氨基]-1,5-二氢-2H-吡咯-2-酮和3-[1-(1H-苯并咪唑-2-基)烷基]-2-取代-4(3H)-喹唑啉酮的合成。五种化合物表现出体外抗菌和抗真菌活性。其中三种化合物在小鼠中针对P-388淋巴细胞白血病进行了测试，结果无活性。
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