School of Biological, Health and Sports Sciences, Technological University Dublin - City Campus, Central Quad, Dublin 7, Grangegorman, D07 XT95, Ireland.
Centre for Endocrinology, Diabetes Mellitus and Metabolism, Saolta University Health Care Group (SUHCG), Galway University Hospitals, Galway, Ireland.
Ir J Med Sci. 2024 Apr;193(2):1061-1071. doi: 10.1007/s11845-023-03543-y. Epub 2023 Oct 21.
Identify the impact of COVID-19 lockdown restrictions on the vitamin D status of individuals in the west of Ireland.
Cross-sectional study.
Adults who had wintertime serum 25(OH)D analysis completed in Galway University Hospital.
A total of 16,725 participants (2015-2020 (n = 13,449) and 2020-2021 (n = 3276)). Baseline demographics; sex, age, origin of the sample and the date of sample collection.
Median serum vitamin D and serum vitamin D concentrations were higher in the 5-month period from October-February 2020-2021 (61 nmol/L (± 36-85 nmol/L) and 60 nmol/L (± 34-85 nmol/L)) respectively, than for the corresponding 5-month period (October-February) in 2015-2020 (53 nmol/L (± 32-78 nmol/L) and 51 nmol/L (± 30-77 nmol/L)) respectively. These changes coincided with a decline in the prevalence of deficiency. In the 5-month period October-February 2020-2021, 19.2% of the population were vitamin D deficient (< 30 nmol/L) compared to 22.5% in the corresponding 5-month period in 2015-2020, and 38.1% were vitamin D deficient (< 50 nmol/L) in the 5-month period October-February 2020-2021 compared to 46.6% in the corresponding 5-month period in 2015-2020. Males were more likely to be deficient at both thresholds (p < 0.001). For the total cohort, at the < 30 nmol/L threshold, inpatients (25.5%) and nursing home residents (34.1%) had higher prevalence of deficiency.
Vitamin D levels were higher in the 5-month period of October-February 2020-2021, and this precipitated a decline in deficiency at both thresholds, indicating that lockdown coincided with enhanced vitamin D status. We postulate that it may be attributable to changes in diet and/or supplementation, or increased sun exposure, but further confirmatory studies are required.
确定科克西部 COVID-19 封锁限制对个体维生素 D 状况的影响。
横断面研究。
在戈尔韦大学医院完成冬季血清 25(OH)D 分析的成年人。
共有 16725 名参与者（2015-2020 年（n=13449）和 2020-2021 年（n=3276））。基线人口统计学数据；性别、年龄、样本来源和样本采集日期。
2020-2021 年 10 月至 2 月的 5 个月期间，血清维生素 D 中位数和血清维生素 D 浓度分别为 61nmol/L（±36-85nmol/L）和 60nmol/L（±34-85nmol/L），高于 2015-2020 年同期（10 月至 2 月）53nmol/L（±32-78nmol/L）和 51nmol/L（±30-77nmol/L）。这些变化与缺乏症的患病率下降相一致。在 2020-2021 年 10 月至 2 月的 5 个月期间，19.2%的人群维生素 D 缺乏（<30nmol/L），而 2015-2020 年同期为 22.5%，在 2020-2021 年 10 月至 2 月的 5 个月期间，38.1%的人群维生素 D 缺乏（<50nmol/L），而 2015-2020 年同期为 46.6%。男性在两个阈值上都更容易出现缺乏（p<0.001）。在总队列中，在<30nmol/L 的阈值下，住院患者（25.5%）和养老院居民（34.1%）缺乏症的患病率更高。
2020-2021 年 10 月至 2 月的 5 个月期间，维生素 D 水平较高，这导致两个阈值的缺乏症下降，表明封锁恰逢维生素 D 状况改善。我们推测这可能归因于饮食和/或补充的变化，或增加的阳光暴露，但需要进一步的证实性研究。
