Scientific and Technological Institute, Brazil University, 08230-030 São Paulo, SP, Brazil.
Sao Carlos Institute of Physics, University of São Paulo, 13566-970 São Carlos, SP, Brazil.
Int J Biol Macromol. 2023 Dec 31;253(Pt 7):127425. doi: 10.1016/j.ijbiomac.2023.127425. Epub 2023 Oct 20.
In the present study, chitosan and chitosan/turmeric-based membranes were produced, characterized and applied in in vivo experiments showing the applicability for skin wound repair. Chitosan 1 % (w/v), chitosan + glycerol 30 % (w/w) and chitosan + glycerol 30 % + turmeric 1.5 % (w/w) membranes were produced through the casting technique. Self-sustainable, homogeneous, and flexible membranes were obtained from all materials tested. The FTIR spectra showed the main vibrational bands for materials used in the chemical groups. The membranes containing glycerol are more flexible than those formed with pure chitosan. Membranes formed with glycerol and glycerol/turmeric are more hydrophilic compared to the membranes formed by pure chitosan. The in vivo results showed that the group who received the chi/gly/turmeric membrane had a statistically greater reduction in the injured area, as well as a better healing process in the histological analysis compared to the other experimental groups. The material developed here is from a natural source, low cost and easy to apply and can accelerate the process of repairing skin lesions.
在本研究中，制备了壳聚糖和基于壳聚糖/姜黄的膜，并对其进行了表征，同时将其应用于体内实验以展示其在皮肤伤口修复中的适用性。通过浇注技术制备了 1%（w/v）壳聚糖、30%（w/w）壳聚糖+甘油和 30%（w/w）壳聚糖+甘油+1.5%（w/w）姜黄的膜。所有测试材料均获得了自支撑、均匀且柔韧的膜。FTIR 光谱显示了用于化学基团的材料的主要振动带。与纯壳聚糖形成的膜相比，含有甘油的膜更具柔韧性。与纯壳聚糖形成的膜相比，由甘油和甘油/姜黄形成的膜具有更高的亲水性。体内结果表明，与其他实验组相比，接受 chi/gly/turmeric 膜的组在受伤区域的减少量以及组织学分析中的愈合过程方面具有统计学上的显著改善。这里开发的材料来源于天然来源，成本低，易于应用，可以加速皮肤损伤的修复过程。
