造血干细胞的演变：一生适应机体需求。
Hematopoietic stem cells through the ages: A lifetime of adaptation to organismal demands.
机构信息
Columbia Stem Cell Initiative, Department of Genetics and Development, Columbia University, New York, NY 10032, USA; Division of Hematology and Medical Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Columbia Stem Cell Initiative, Department of Genetics and Development, Columbia University, New York, NY 10032, USA.
出版信息
Cell Stem Cell. 2023 Nov 2;30(11):1403-1420. doi: 10.1016/j.stem.2023.09.013. Epub 2023 Oct 20.
Abstract
Hematopoietic stem cells (HSCs), which govern the production of all blood lineages, transition through a series of functional states characterized by expansion during fetal development, functional quiescence in adulthood, and decline upon aging. We describe central features of HSC regulation during ontogeny to contextualize how adaptive responses over the life of the organism ultimately form the basis for HSC functional degradation with age. We particularly focus on the role of cell cycle regulation, inflammatory response pathways, epigenetic changes, and metabolic regulation. We then explore how the knowledge of age-related changes in HSC regulation can inform strategies for the rejuvenation of old HSCs.
摘要
造血干细胞（HSCs）主宰着所有血液谱系的生成，它们通过一系列功能状态进行转变，这些状态在胎儿发育期间经历扩张，在成年期处于功能静止状态，并随着衰老而衰退。我们描述了 HSC 在个体发生过程中的调节的主要特征，以说明生物体一生中的适应性反应如何最终构成 HSC 随年龄功能退化的基础。我们特别关注细胞周期调节、炎症反应途径、表观遗传变化和代谢调节的作用。然后，我们探讨了了解 HSC 调节的与年龄相关的变化如何为老年 HSCs 的年轻化策略提供信息。
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