Doheny Eye Institute, Pasadena, CA, USA.
Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Eye (Lond). 2024 Apr;38(5):847-852. doi: 10.1038/s41433-023-02788-2. Epub 2023 Oct 21.
To evaluate the effect of changing slab position on the correlation between choriocapillaris (CC) flow deficits (FD) in eyes with geographic atrophy (GA) and yearly enlargement rate (yER) of GA.
OCT and OCTA images obtained on Cirrus HD-OCT device were collected from patients with GA. Each patient underwent OCTA scan at baseline and two OCT scans, one at baseline and one after at least 12 months. GA was delineated on en-face fundus image to calculate yER. OCTA images were generated from three 10 µm thick slabs 11, 21 and 31 µm posterior to RPE-fit line. 100 µm-wide concentric rings were generated around GA to calculate FD% in each ring which was correlated with yER.
For the 11-21 µm slab, FD% was not significantly correlated with yER for any of the rings (p > 0.05). For the 21-31 and 31-41 µm slab, FD% of rings located in the 600 µm region around GA was significantly correlated with yER (p < 0.05). However, in all slab locations, there was no significant correlation between yER and CC FD% of rings located beyond the 600 µm region (p > 0.05).
Slab selection for quantification of CC FD% may have a significant impact on quantitative results in eyes with GA.
评估改变层面位置对脉络膜毛细血管（CC）血流缺损（FD）与地图样萎缩（GA）每年扩大率（yER）之间相关性的影响。
从患有 GA 的患者中收集 Cirrus HD-OCT 设备获得的 OCT 和 OCTA 图像。每位患者在基线和至少 12 个月后进行一次 OCT 扫描，在基线和一次 OCT 扫描中进行 OCTA 扫描。在眼底图像上对 GA 进行描绘，以计算 yER。从 RPE-拟合线后 11、21 和 31 μm 处的三个 10 μm 厚的层生成 OCTA 图像。在 GA 周围生成 100 μm 宽的同心环，以计算每个环中的 FD%，并将其与 yER 相关联。
对于 11-21 μm 层，任何环的 FD%与 yER 均无显著相关性（p>0.05）。对于 21-31 和 31-41 μm 层，位于 GA 周围 600 μm 区域的环的 FD%与 yER 显著相关（p<0.05）。然而，在所有层面位置，位于 GA 之外的 600 μm 区域的环的 yER 与 CC FD%之间均无显著相关性（p>0.05）。
用于量化 CC FD%的层面选择可能会对 GA 眼中的定量结果产生重大影响。
