Department of Surgery, Institut Jules Bordet (Hopitaux Universitaires de Bruxelles [HUB]), Université Libre de Bruxelles, Brussels, Belgium.
Department of Pathology, Institut Jules Bordet (Hopitaux Universitaires de Bruxelles [HUB]), Université Libre de Bruxelles, Brussels, Belgium.
Ann Surg Oncol. 2024 Jan;31(1):605-613. doi: 10.1245/s10434-023-14405-3. Epub 2023 Oct 22.
The most common mode of ovarian cancer (OC) spread is intraperitoneal dissemination, with the peritoneum as the primary site of metastasis. Cytoreductive surgery (CRS) with chemotherapy is the primary treatment. When necessary, a digestive resection can be performed, but the role of mesenteric lymph nodes (MLNs) in advanced OC remains unclear, and its significance in treatment and follow-up evaluation remains to be determined. This study aimed to evaluate the prevalence of MLN involvement in patients who underwent digestive resection for OC peritoneal metastases (PM) and to investigate its potential prognostic value.
This retrospective, descriptive study included patients who underwent CRS with curative intent for OC with PM between 1 January 2007 and 31 December 2020. The study assessed MLN status and other clinicopathologic features to determine their prognostic value in relation to overall survival (OS) and progression-free survival (PFS).
The study enrolled 159 women with advanced OC, 77 (48.4%) of whom had a digestive resection. For 61.1% of the patients who underwent digestive resection, MLNs were examined and found to be positive in 56.8%. No statistically significant associations were found between MLN status and OS (p = 0.497) or PFS ((p = 0.659).
In anatomopathologic studies, MLNs are not systematically investigated but are frequently involved. In the current study, no statistically significant associations were found between MLN status and OS or PFS. Further prospective studies with a systematic and standardized approach should be performed to confirm these findings.
卵巢癌（OC）最常见的播散模式是腹腔内播散，腹膜是转移的主要部位。细胞减灭术（CRS）联合化疗是主要治疗方法。必要时可进行消化道切除术，但在晚期 OC 中肠系膜淋巴结（MLNs）的作用尚不清楚，其在治疗和随访评估中的意义仍有待确定。本研究旨在评估接受 OC 腹膜转移（PM）消化道切除术的患者 MLN 受累的发生率，并探讨其在预后中的潜在价值。
本回顾性描述性研究纳入 2007 年 1 月 1 日至 2020 年 12 月 31 日期间接受 CRS 治疗的 OC 伴 PM 的患者。研究评估了 MLN 状态和其他临床病理特征，以确定其与总生存（OS）和无进展生存（PFS）的关系的预后价值。
本研究共纳入 159 例晚期 OC 患者，其中 77 例（48.4%）接受了消化道切除术。61.1%的接受消化道切除术的患者检查了 MLN，发现有 56.8%的 MLN 阳性。MLN 状态与 OS（p = 0.497）或 PFS（p = 0.659）无统计学显著相关性。
在解剖病理学研究中，MLN 并非系统性检查，但常受累。在本研究中，MLN 状态与 OS 或 PFS 之间未发现统计学显著相关性。应进一步进行系统的、标准化的前瞻性研究，以证实这些发现。
