Berek Jonathan S, Renz Malte, Kehoe Sean, Kumar Lalit, Friedlander Michael
Stanford Women's Cancer Center, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA.
Oxford Gynecological Cancer Center, Churchill Hospital, Oxford, UK.
Int J Gynaecol Obstet. 2021 Oct;155 Suppl 1(Suppl 1):61-85. doi: 10.1002/ijgo.13878.
In 2014, FIGO's Committee for Gynecologic Oncology revised the staging of ovarian cancer, incorporating ovarian, fallopian tube, and peritoneal cancer into the same system. Most of these malignancies are high-grade serous carcinomas (HGSC). Stage IC is now divided into three categories: IC1 (surgical spill); IC2 (capsule ruptured before surgery or tumor on ovarian or fallopian tube surface); and IC3 (malignant cells in the ascites or peritoneal washings). The updated staging includes a revision of Stage IIIC based on spread to the retroperitoneal lymph nodes alone without intraperitoneal dissemination. This category is now subdivided into IIIA1(i) (metastasis ≤10 mm in greatest dimension), and IIIA1(ii) (metastasis >10 mm in greatest dimension). Stage IIIA2 is now "microscopic extrapelvic peritoneal involvement with or without positive retroperitoneal lymph node" metastasis. This review summarizes the genetics, surgical management, chemotherapy, and targeted therapies for epithelial cancers, and the treatment of ovarian germ cell and stromal malignancies.
2014年，国际妇产科联盟（FIGO）妇科肿瘤委员会修订了卵巢癌的分期，将卵巢癌、输卵管癌和腹膜癌纳入同一系统。这些恶性肿瘤大多为高级别浆液性癌（HGSC）。目前，IC期分为三类：IC1（手术中肿瘤破溃）；IC2（手术前包膜破裂或卵巢或输卵管表面有肿瘤）；以及IC3（腹水或腹腔冲洗液中有恶性细胞）。更新后的分期包括对IIIC期的修订，该期仅基于肿瘤扩散至腹膜后淋巴结而无腹腔内播散。此类别现细分为IIIA1（i）（最大径≤10 mm的转移灶）和IIIA1（ii）（最大径>10 mm的转移灶）。IIIA2期现定义为“镜下盆腔外腹膜受累伴或不伴腹膜后淋巴结转移阳性”。本综述总结了上皮性癌的遗传学、手术治疗、化疗和靶向治疗，以及卵巢生殖细胞和间质恶性肿瘤的治疗。
