Department of Animal Physiology, Biochemistry and Biostructure, Faculty of Veterinary Medicine and Animal Science, University of Life Sciences, Poznan, Poland.
Department of Paediatric Orthopaedics and Traumatology, Faculty of Medicine, Poznan University of Medical Sciences, Poznan, Poland.
J Physiol Pharmacol. 2023 Aug;74(4). doi: 10.26402/jpp.2023.4.06. Epub 2023 Oct 16.
Overweight and obesity are associated with severe metabolic disorders and an increased risk of cardiovascular diseases. It is a known fact that physical activity has a positive effect on metabolic parameters, and also reduces the risk of diseases such as diabetes. Some products can enhance the rate of lipolysis and help in improving fat loss. One of these are selective androgen receptor modulators (SARMs) which act as anabolic agents and are also believed to aid in fat-burning. In this study, we investigated whether 30 days of ostarine administration could potentially improve metabolic parameters using the rat model of obesity combined with exercise. We assessed the levels of biochemical and hormonal parameters in serum samples as well as insulin sensitivity indices of tissues. There were significant changes in the metabolic parameters with exercise. However, we did not find any additive effects of ostarine and exercise on most of the parameters tested. Similar results were obtained from the analysis of gene expression and the concentration of leptin and adiponectin. Our results indicated that ostarine had a lowering effect on cholesterol concentration in the serum (P<0.05). Moreover, when combining ostarine and exercise, additive changes were only observed in the levels of total and HDL cholesterol. No significant change was observed in the metabolic parameters of obese rats with the use of ostarine at the dose of 0.4 mg/kg body weight. Since ostarine is known to enhance performance, further research on its effects is needed.
超重和肥胖与严重的代谢紊乱和心血管疾病风险增加有关。众所周知，身体活动对代谢参数有积极影响，还可以降低糖尿病等疾病的风险。一些产品可以提高脂肪分解率，有助于减少脂肪。其中一种是选择性雄激素受体调节剂（SARMs），它们作为合成代谢剂，也被认为有助于燃烧脂肪。在这项研究中，我们使用肥胖合并运动的大鼠模型，研究了 30 天奥沙利肽给药是否可能改善代谢参数。我们评估了血清样本中生化和激素参数以及组织胰岛素敏感性指数。运动对代谢参数有显著影响。然而，我们没有发现奥沙利肽和运动对大多数测试参数有任何附加作用。基因表达分析和瘦素和脂联素浓度的结果也得到了类似的结果。我们的结果表明，奥沙利肽对血清胆固醇浓度有降低作用（P<0.05）。此外，当奥沙利肽和运动结合使用时，仅观察到总胆固醇和高密度脂蛋白胆固醇水平的附加变化。在使用 0.4mg/kg 体重的奥沙利肽时，肥胖大鼠的代谢参数没有显著变化。由于奥沙利肽已知可以提高性能，因此需要对其作用进行进一步研究。
