MacLean A W, Knowles J B, Vetere C
Psychiatry Res. 1986 Sep;19(1):25-36. doi: 10.1016/0165-1781(86)90089-2.
A phase advance of the circadian rhythm of rapid eye movement (REM) sleep propensity relative to the sleep-wake cycle has been proposed to account for the abnormalities of REM sleep commonly found in depressed patients. One implication of this hypothesis is that a phase delay of sleep in normal subjects should produce the same abnormalities of REM sleep. The hypothesis was tested by computer simulation using equations based on data derived from normal subjects who had experienced phase shifts of their bedtime. At phase delays of between 4 and 6 hours (an estimate of the putative phase advance in depressed patients), the mean REM latency and the mean duration of the first REM period predicted by the equations did not differ significantly from those observed in depressed patients. The findings with respect to the distribution of REM latency were more equivocal.
快速眼动（REM）睡眠倾向的昼夜节律相对于睡眠-觉醒周期提前，这被认为可以解释抑郁症患者中常见的REM睡眠异常。该假说的一个含义是，正常受试者的睡眠相位延迟应该会产生相同的REM睡眠异常。通过计算机模拟对该假说进行了测试，模拟使用的方程基于来自经历过就寝时间相位偏移的正常受试者的数据。在4至6小时的相位延迟（对抑郁症患者假定的相位提前的估计）下，方程预测的平均REM潜伏期和第一个REM期的平均持续时间与抑郁症患者中观察到的没有显著差异。关于REM潜伏期分布的研究结果则更不明确。
