Department of Radiology, University Hospital of North Norway, Tromsø, Norway; Department of Clinical Medicine, Faculty of Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Department of Radiology, University Hospital of North Norway, Tromsø, Norway; Department of Clinical Medicine, Faculty of Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
J Stroke Cerebrovasc Dis. 2023 Dec;32(12):107399. doi: 10.1016/j.jstrokecerebrovasdis.2023.107399. Epub 2023 Oct 20.
Data on prevalence of intracranial artery stenosis (ICAS) in Western populations is sparse. The aim of the study was to assess the prevalence and risk factors for ICAS in a mainly Caucasian general population.
We assessed the prevalence of ICAS in 1847 men and women aged 40 to 84 years who participated in a cross-sectional population-based study, using 3-dimensional time-of-flight 3 Tesla magnetic resonance angiography. ICAS was defined as a focal luminal flow diameter reduction of ≥50 %. The association between cardiovascular risk factor levels and ICAS was assessed by multivariable regression analysis.
The overall prevalence of ICAS was 6.0 % (95 % confidence interval (CI) 5.0-7.2), 4.3 % (95 % CI 3.1-5.7) in women and 8.0 % (95 % CI 6.3-10.0) in men. The prevalence increased by age from 0.8 % in 40-54 years age group to 15.2 % in the 75-84 years age group. The majority of stenoses was located to the internal carotid artery (52.2 %), followed by the posterior circulation (33.1 %), the middle cerebral artery (10.8 %) and the anterior cerebral artery (3.8 %). The risk of ICAS was independently associated with higher age, male sex, hypertension, hyperlipidemia, diabetes mellitus, current smoking and higher BMI.
The prevalence of ICAS in a general population of Caucasians was relatively high and similar to the prevalence of extracranial internal carotid artery stenosis in previous population-based studies.
西方人群颅内动脉狭窄（ICAS）的患病率数据较为匮乏。本研究旨在评估一个以白种人为主的普通人群中 ICAS 的患病率和危险因素。
我们使用 3 特斯拉磁共振血管造影的三维时间飞跃技术评估了 1847 名年龄在 40 至 84 岁之间的男女参与者中 ICAS 的患病率。ICAS 定义为局灶性管腔血流直径减少≥50%。采用多变量回归分析评估心血管危险因素水平与 ICAS 之间的关联。
ICAS 的总体患病率为 6.0%（95%置信区间[CI] 5.0-7.2），女性为 4.3%（95%CI 3.1-5.7），男性为 8.0%（95%CI 6.3-10.0）。患病率随年龄增长而增加，40-54 岁年龄组为 0.8%，75-84 岁年龄组为 15.2%。大多数狭窄位于颈内动脉（52.2%），其次是后循环（33.1%）、大脑中动脉（10.8%）和大脑前动脉（3.8%）。ICAS 的风险与年龄较大、男性、高血压、高血脂、糖尿病、当前吸烟和较高的 BMI 独立相关。
在一个白种人普通人群中，ICAS 的患病率相对较高，与之前基于人群的研究中外侧颈内动脉狭窄的患病率相似。
