Lenz Luana Suéling, Torgo Daphne, Buss Julieti Huch, Pereira Luiza Cherobini, Bueno Mardja, Filippi-Chiela Eduardo Cremonese, Lenz Guido
Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil; Departamento de Biofísica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
Exp Cell Res. 2023 Dec 15;433(2):113825. doi: 10.1016/j.yexcr.2023.113825. Epub 2023 Oct 21.
Metabolic adaptations are central for carcinogenesis and response to therapy, but little is known about the contribution of mitochondrial dynamics to the response of glioma cells to the standard treatment with temozolomide (TMZ). Glioma cells responded to TMZ with mitochondrial mass increased and the production of round structures of dysfunctional mitochondria. At single-cell level, asymmetric mitosis contributed to the heterogeneity of mitochondrial levels. It affected the fitness of cells in control and treated condition, indicating that the mitochondrial levels are relevant for glioma cell fitness in the presence of TMZ.
代谢适应是致癌作用和治疗反应的核心，但关于线粒体动力学对胶质瘤细胞对替莫唑胺（TMZ）标准治疗反应的贡献知之甚少。胶质瘤细胞对TMZ的反应是线粒体质量增加以及出现功能失调的圆形线粒体结构。在单细胞水平上，不对称有丝分裂导致线粒体水平的异质性。它影响了对照和处理条件下细胞的适应性，表明线粒体水平与TMZ存在时胶质瘤细胞的适应性相关。
