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非大面积烧伤患者的输血治疗。

Blood transfusions in non-major burns patients.

机构信息

University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj Napoca, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania; Emergency County Hospital, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania; Department of Haematology "Ion Chiricuta" Institute of Oncology, 34-36 Republicii Street, Cluj-Napoca 400015, Romania.

Department of Haematology "Ion Chiricuta" Institute of Oncology, 34-36 Republicii Street, Cluj-Napoca 400015, Romania.

出版信息

Burns. 2023 Dec;49(8):1808-1815. doi: 10.1016/j.burns.2023.09.018. Epub 2023 Sep 30.

Abstract

BACKGROUND

Blood transfusions are essential to treating anaemia of burn injuries. It has recently been observed that patients with non-major burns < 20%TBSA may also develop anaemia requiring transfusion of blood products. Due to the morbidity and mortality rate associated with blood transfusions better understanding of risk factors may guide clinical practices to improve patient care.

OBJECTIVE

To determine risk factors for transfusion of blood products in patients with non-major burn injuries and assess transfusion practices to establish impact on patient outcome.

METHOD

Our study included 182 adult patients with non-major burn injuries, < 20%TBSA admitted over a 3-year period at the Department of Plastic Surgery and Burns Unit of the Emergency County Hospital Cluj-Napoca. We analysed patient and injury characteristics: age, gender, %TBSA burn, %FT burn, burn site, mechanism of injury, inhalation injury, Hb lab determinations throughout admission and surgical management. Charlson comorbidities index has been determined based on cardiovascular, neurological, gastrointestinal and renal comorbidities as well as diabetes mellitus. We selected blood transfusions, wound infections and length of hospital stay as outcome for our analysis.

RESULTS

37.9% of patients included in our study developed anaemia throughout admission and 7.7% underwent blood transfusions. Mean Hb levels triggering blood transfusions have been recorded at 7.4 (IQR=8.8-9.9) g/dL. Patients who received transfusions were older, presented with higher %TBSA and associated a higher comorbidity index. They also tended to develop coagulopathy and underwent more surgical procedures to achieve wound closure. In transfused patients who associate comorbidities we observed a higher rate of wound infections and longer hospital stay.

CONCLUSIONS

Patient related comorbidities correlate with higher transfusion rates in non-major burn injuries. Due to the risk associated with the use of blood products decision to transfuse should adhere to current guideline practices and be tailored to specific patient requirements.

摘要

背景

输血对于治疗烧伤引起的贫血至关重要。最近观察到,非大面积烧伤<20%TBSA 的患者也可能出现贫血,需要输注血液制品。由于输血相关的发病率和死亡率,更好地了解危险因素可能有助于指导临床实践,改善患者的治疗效果。

目的

确定非大面积烧伤患者输血的危险因素,并评估输血实践对患者结局的影响。

方法

我们的研究纳入了在过去 3 年期间于克卢日-纳波卡紧急县医院整形和烧伤科就诊的 182 名非大面积烧伤、<20%TBSA 的成年患者。我们分析了患者和损伤特征:年龄、性别、TBSA 烧伤百分比、FT 烧伤百分比、烧伤部位、损伤机制、吸入性损伤、整个住院期间的 Hb 实验室测定值以及手术管理。Charlson 合并症指数是根据心血管、神经、胃肠道和肾脏合并症以及糖尿病来确定的。我们选择输血、伤口感染和住院时间作为分析的结局。

结果

我们的研究中,37.9%的患者在住院期间出现贫血,7.7%的患者接受了输血。触发输血的平均 Hb 水平记录为 7.4(IQR=8.8-9.9)g/dL。接受输血的患者年龄较大,TBSA 百分比较高,合并症指数较高。他们也倾向于发生凝血功能障碍,并接受更多的手术来实现伤口闭合。在合并症的输血患者中,我们观察到伤口感染的发生率更高,住院时间更长。

结论

患者相关的合并症与非大面积烧伤患者的更高输血率相关。由于血液制品使用的相关风险,输血的决定应遵循当前的指南实践,并根据特定患者的需求进行调整。

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