植物染色质重塑因子综合数据库（PlantCHRs）
PlantCHRs: A comprehensive database of plant chromatin remodeling factors.
作者信息
Yan Hengyu, Liu Fangyuan, Zhang Guowei, Liu Shuai, Ma Weiwei, Yang Ting, Li Yubin, Yang Jiaotong, Cui Hailong
机构信息
College of Agronomy, Qingdao Agricultural University, China.
Resource Institute for Chinese and Ethnic Materia Medica, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
出版信息
Comput Struct Biotechnol J. 2023 Oct 5;21:4974-4987. doi: 10.1016/j.csbj.2023.10.005. eCollection 2023.
The Snf2 protein family is a group of ATP-dependent chromatin remodeling factors (CHRs) that play an essential role in gene expression regulation. In plants, Snf2 is involved in growth, development, as well as stress resistance. However, only a very limited number of experimentally validated Snf2 have been identified and reported, while the majority remaining undiscovered in most species . In this study, we predicted 3135 Snf2 proteins and 8398 chromatin remodeling complex (CRC) subunits in diverse plant species, and constructed the Plant Chromatin Remodeling Factors Database (PlantCHRs, http://www.functionalgenomics.cn/PlantCHRs/), which provide a comprehensive resource for researchers to access information about plant CHRs. We also developed an online tool capable of predicting CHRs and CRC subunits. Moreover, we investigated the distribution of Snf2 proteins in different species and observed a significant increase in the number of Snf2 proteins and the diversity of the Snf2 subfamily during the evolution, highlighting their evolutionary importance. By analyzing the expression patterns of the Snf2 genes in different tissues of maize and , we found that the Snf2 proteins may show some conservation across different species in regulating plant growth and development. Over the all, we established a comprehensive database for plant CHRs, which will facilitate the researches on plant chromatin remodeling.
Snf2蛋白家族是一组依赖ATP的染色质重塑因子（CHRs），在基因表达调控中发挥着重要作用。在植物中，Snf2参与生长、发育以及抗逆性。然而，目前仅鉴定和报道了极少数经过实验验证的Snf2，而在大多数物种中，大多数Snf2仍未被发现。在本研究中，我们预测了多种植物物种中的3135个Snf2蛋白和8398个染色质重塑复合体（CRC）亚基，并构建了植物染色质重塑因子数据库（PlantCHRs，http://www.functionalgenomics.cn/PlantCHRs/），为研究人员提供了一个获取植物CHRs信息的综合资源。我们还开发了一种能够预测CHRs和CRC亚基的在线工具。此外，我们研究了Snf2蛋白在不同物种中的分布，发现在进化过程中Snf2蛋白的数量显著增加，Snf2亚家族的多样性也显著增加，突出了它们在进化中的重要性。通过分析玉米不同组织中Snf2基因的表达模式，我们发现Snf2蛋白在调控植物生长发育方面可能在不同物种间表现出一定的保守性。总体而言，我们建立了一个植物CHRs的综合数据库，这将有助于植物染色质重塑的研究。
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