大肠淀粉样变性所致的胃肠道出血
Gastrointestinal Bleeding Caused by Large Intestine Amyloidosis.
作者信息
Seth Nikhil, Jaeger Victoria A, Thapa Namisha, Sing James T, Naumann Christopher R
机构信息
Central Texas Veterans Affairs Health Care System, Temple.
Baylor Scott and White Medical Center, Temple, Texas.
出版信息
Fed Pract. 2023 Aug;40(8):262-264. doi: 10.12788/fp.0389. Epub 2023 Aug 18.
BACKGROUND
Amyloidosis is a rare disorder caused by abnormal folding of proteins, leading to the dysfunction of normal tissues. Amyloid deposition can affect several organs, but deposition in the large intestine is rare.
CASE PRESENTATION
A 79-year-old man presented with gastrointestinal bleeding and nonspecific symptoms of weight loss, dry heaves, dysphagia, and weakness. The patient underwent esophagogastroduodenoscopy and colonoscopy and a biopsy confirmed the diagnosis of intestinal amyloidosis.
CONCLUSIONS
This case report highlights the importance of a strong differential when working up gastrointestinal bleeding that includes amyloidosis. Early identification and multidisciplinary involvement are crucial for management and tailored care to each patient's needs.
背景
淀粉样变性是一种由蛋白质异常折叠引起的罕见疾病，可导致正常组织功能障碍。淀粉样沉积可影响多个器官，但在大肠中的沉积很少见。
病例介绍
一名79岁男性出现胃肠道出血以及体重减轻、干呕、吞咽困难和虚弱等非特异性症状。患者接受了食管胃十二指肠镜检查和结肠镜检查，活检确诊为肠道淀粉样变性。
结论
本病例报告强调了在检查包括淀粉样变性在内的胃肠道出血时进行全面鉴别诊断的重要性。早期识别和多学科参与对于管理以及根据每个患者的需求提供个性化护理至关重要。
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