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粘质沙雷氏菌污染洗必泰溶液导致多条带隧道透析导管感染

Infection of Multiple Tunneled Dialysis Catheters Resulting From the Contamination of the Chlorhexidine Solution by Serratia marcescens.

作者信息

Gomes Cochicho Joana, Silva José Miguel, Viegas Marcio

机构信息

Internal Medicine Department, Hospital Doutor José Maria Grande, Portalegre, PRT.

Hemodialysis Department, Centro de Portalegre, Fundação Renal Portuguesa, Portalegre, PRT.

出版信息

Cureus. 2023 Sep 21;15(9):e45693. doi: 10.7759/cureus.45693. eCollection 2023 Sep.

Abstract

Tunnelled dialysis catheters continue to be a choice in several patients as hemodialysis access. According to Kidney Disease Outcomes Quality Initiative guidelines, its handling implies disinfection, that can be performed using chlorhexidine solutions. Theoretically, these solutions have bactericidal capacity at concentrations greater than 0.12%. We present a curious situation of failure of the antiseptic process due to contamination of the chlorhexidine solution 4% of aqueous base. In this hemodialysis clinic, three cases of infections by the bacteria were identified over 2 weeks - in two of the cases, identified in blood culture, and in the other case in the exudate from the exit site of the catheter. Considering the abnormal number of infections by this agent and the fact that these patients were on different shifts, were treated in different rooms, and handled by different nurses, the antiseptic solutions used in the different hemodialysis rooms were analyzed, as well as a closed package from the same batch. After microbiological tests were performed on the antiseptic solution, we identified the growth of . This result identified the culprit as being the contamination of the 4% chlorhexidine solution. The competent authorities were notified, and the disinfection method was changed to use a chlorhexidine alcohol-based solution.

摘要

隧道式透析导管仍然是一些患者进行血液透析通路的选择。根据《肾脏病预后质量倡议》指南,其操作需要进行消毒,可使用洗必泰溶液。理论上,这些溶液在浓度大于0.12%时具有杀菌能力。我们呈现了一种因4%水基洗必泰溶液污染导致消毒过程失败的奇特情况。在这家血液透析诊所,两周内发现了3例由该细菌引起的感染病例——其中2例在血培养中被鉴定出来,另一例在导管出口部位的渗出物中被鉴定出来。考虑到该病原体感染病例数量异常,且这些患者在不同班次、不同房间接受治疗,由不同护士操作,我们对不同血液透析房间使用的消毒溶液以及同一批次的未开封包装进行了分析。对消毒溶液进行微生物检测后,我们鉴定出了 的生长。这一结果确定罪魁祸首是4%洗必泰溶液受到了污染。我们已通知相关主管部门,并将消毒方法改为使用酒精基洗必泰溶液。

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Serratia marcescens outbreak due to contaminated 2% aqueous chlorhexidine.因2%洗必泰水溶液污染导致的粘质沙雷氏菌暴发。
Enferm Infecc Microbiol Clin. 2017 Dec;35(10):624-629. doi: 10.1016/j.eimc.2016.06.016. Epub 2016 Aug 3.

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Killing of Serratia marcescens biofilms with chloramphenicol.用氯霉素杀灭粘质沙雷氏菌生物膜。
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