Chálim Rebelo Carolina, Félix Catarina, Cardoso Filipe S, Bagulho Luis, Sousa Monica, Mendes Milena, Glória Helena, Mateus Élia, Mega Inês, Jara Miguel, Pinto Marques Hugo, Nolasco Fernando, Martins Américo, Perdigoto Rui
Gastroenterology Division, Divino Espírito Santo Hospital, Ponta Delgada, Portugal.
Gastroenterology Division, Western Lisbon Hospital Center, Lisbon, Portugal.
GE Port J Gastroenterol. 2022 Oct 17;30(5):343-349. doi: 10.1159/000525808. eCollection 2023 Oct.
Listing patients with alcohol-associated liver disease (ALD) for liver transplant (LT) remains challenging especially due to the risk of alcohol resumption post-LT. We aimed to evaluate post-LT alcohol consumption at a Portuguese transplant center.
We conducted a cross-sectional study including LT recipients from 2019 at Curry Cabral Hospital, Lisbon, Portugal. A pretested survey and a validated Portuguese translation of the Alcohol Use Disorder Identification Test (AUDIT) were applied via a telephone call. Alcohol consumption was defined by patients' self-reports or a positive AUDIT.
In 2019, 122 patients underwent LT, and 99 patients answered the survey (June 2021). The mean (SD) age was 57 (10) years, 70 patients (70.7%) were males, and 49 (49.5%) underwent ALD-related LT. During a median (IQR) follow-up of 24 (20-26) months post-index LT, 22 (22.2%) recipients consumed any amount of alcohol: 14 had a drink monthly or less and 8 drank 2-4 times/month. On drinking days, 18 patients usually consumed 1-2 drinks and the remainder no more than 3-4 drinks. One patient reported having drunk ≥6 drinks on one occasion. All post-LT drinking recipients were considered low risk (score <8) as per the AUDIT score (median [IQR] of 1 [1-2]). No patient reported alcohol-related problems, whether self-inflicted or toward others. Drinking recipients were younger (53 vs. 59 years, = 0.020), had more non-ALD-related LT (72.7 vs. 44.2%, = 0.018) and active smoking (31.8 vs. 10.4%, = 0.037) than abstinent ones.
In our cohort, about a quarter of LT recipients consumed alcohol early posttransplant, all with a low-risk pattern according to the AUDIT score.
将酒精性肝病（ALD）患者列入肝移植（LT）名单仍然具有挑战性，特别是由于肝移植后存在重新饮酒的风险。我们旨在评估葡萄牙一家移植中心肝移植后的酒精消费情况。
我们进行了一项横断面研究，纳入了2019年在葡萄牙里斯本库里卡布拉尔医院接受肝移植的患者。通过电话应用了一份预先测试的调查问卷和经过验证的葡萄牙语版酒精使用障碍识别测试（AUDIT）。酒精消费由患者自我报告或AUDIT阳性定义。
2019年，122例患者接受了肝移植，99例患者回答了调查（2021年6月）。平均（标准差）年龄为57（10）岁，70例患者（70.7%）为男性，49例（49.5%）接受了与ALD相关的肝移植。在索引肝移植后的中位（四分位间距）随访24（20 - 26）个月期间，22例（22.2%）受者饮用了任何量的酒精：14例每月饮酒一次或更少，8例每月饮酒2 - 4次。在饮酒日，18例患者通常饮用1 - 2杯酒，其余患者饮酒不超过3 - 4杯。1例患者报告曾有一次饮酒≥6杯。根据AUDIT评分（中位数[四分位间距]为1[1 - 2]），所有肝移植后饮酒的受者均被视为低风险（评分<8）。没有患者报告与酒精相关的问题，无论是对自身还是对他人。饮酒的受者比戒酒的受者更年轻（53岁对59岁，P = 0.020），接受非ALD相关肝移植的比例更高（72.7%对44.2%，P = 0.018），且吸烟率更高（31.8%对10.4%，P = 0.037）。
在我们的队列中，约四分之一的肝移植受者在移植后早期饮酒，根据AUDIT评分，所有患者的饮酒模式均为低风险。
