Yano Takuya, Ohira Masahiro, Sakamoto Ryoko, Narisada Aiko, Shimizu Seiichi, Tahara Hiroyuki, Ide Kentaro, Kobayashi Tsuyoshi, Imamura Michio, Machino Akihiko, Yamawaki Shigeto, Chayama Kazuaki, Ohdan Hideki
Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Transplant Proc. 2019 Jul-Aug;51(6):1934-1938. doi: 10.1016/j.transproceed.2019.02.031.
Excessive alcohol consumption has a negative impact on graft survival after liver transplantation (LT). However, it is difficult to predict alcohol relapse before LT. This study surveyed the alcohol consumption of LT recipients to identify the risk factors for harmful drinking. We surveyed the alcohol consumption of LT recipients by using the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C). AUDIT-C scores ≥ 5 points in men and ≥ 4 points in women indicated a high risk for harmful and hazardous drinking. Excessive alcohol consumption was considered to be > 20 g per day. Ninety-nine LT recipients completely filled out the questionnaire. Alcohol consumption after LT was detected in 26 recipients (26.5%); 4 of them had alcoholic liver disease before transplantation and 22 did not have alcoholic liver disease. The amount of alcohol consumption per day significantly decreased after LT (alcohol consumption per day: 49.6 g before LT vs 8.1 g after LT, P < .05). Fourteen recipients (14.1%) consumed alcohol excessively after LT. The AUDIT-C score before LT and smoking were risk factors for excessive alcohol consumption in the multivariate analysis. To properly manage post-transplant recipients, assessing the risk of excessive alcohol consumption by using the AUDIT-C is necessary.
过量饮酒对肝移植（LT）后的移植物存活有负面影响。然而，在肝移植前很难预测酒精复饮情况。本研究调查了肝移植受者的饮酒情况，以确定有害饮酒的风险因素。我们使用酒精使用障碍识别测试-消费版（AUDIT-C）对肝移植受者的饮酒情况进行了调查。男性AUDIT-C评分≥5分且女性≥4分表明有害和危险饮酒的风险较高。过量饮酒被认为是每天>20克。99名肝移植受者完整填写了问卷。26名受者（26.5%）在肝移植后被检测到有饮酒行为；其中4人在移植前患有酒精性肝病，22人没有酒精性肝病。肝移植后每天的饮酒量显著减少（肝移植前每天饮酒量：49.6克 vs 肝移植后8.1克，P <.05）。14名受者（14.1%）在肝移植后过量饮酒。在多变量分析中，肝移植前的AUDIT-C评分和吸烟是过量饮酒的风险因素。为了妥善管理移植后受者，有必要使用AUDIT-C评估过量饮酒的风险。
