Shah Bushra, Ahmad Mah Noor, Khalid Musfira, Minhas Amna, Ali Ramsha, Sarfraz Zouina, Sarfraz Azza
Fatima Jinnah Medical University, Lahore, Pakistan.
The Aga Khan University, Karachi, Pakistan.
J Community Hosp Intern Med Perspect. 2023 Sep 2;13(5):23-31. doi: 10.55729/2000-9666.1233. eCollection 2023.
Pulmonary embolism (PE) is a serious medical condition that can occur as a result of venous thromboembolism (VTE). COVID-19, also known as Post-Acute Sequelae of SARS-CoV-2 infection (PASC), can potentially lead to PE due to the formation of blood clots in the lungs. This study aims to collate and report trends of PE in patients with long COVID (4-12 weeks since infection) and post-COVID-19 syndrome (>12 weeks since infection). The study adhered to PRISMA Statement 2020 guidelines, and a systematic search was conducted in four databases. In total, nine observational studies were included with a total patient count of 45,825,187. The incidence of PE with long COVID/post-COVID-19 syndrome was seen among 31,885 individuals out of 44,967,887 participants. The incidence rate of PE was observed as 0.07%, given that the studies included matched controls. While we cannot state with certainty that COVID-19 infection in itself leads to higher risks of PE at a later time, this study emphasizes the need for optimized care and longitudinal studies during the COVID-19 era to account for deviations from the norm.
肺栓塞（PE）是一种严重的病症，可由静脉血栓栓塞症（VTE）引发。新型冠状病毒肺炎（COVID-19），也称为严重急性呼吸综合征冠状病毒2感染的急性后遗症（PASC），由于肺部形成血凝块，有可能导致肺栓塞。本研究旨在整理并报告新冠后长期症状患者（感染后4至12周）和新冠后综合征患者（感染后超过12周）中肺栓塞的趋势。该研究遵循2020年PRISMA声明指南，并在四个数据库中进行了系统检索。总共纳入了9项观察性研究，患者总数为45,825,187人。在44,967,887名参与者中，有31,885人出现了新冠后长期症状/新冠后综合征相关的肺栓塞。鉴于这些研究纳入了匹配的对照组，肺栓塞的发病率为0.07%。虽然我们不能确定新冠病毒感染本身会在后期导致更高的肺栓塞风险，但本研究强调在新冠疫情期间需要优化护理并开展纵向研究，以应对与正常情况的偏差。
