Zhang Xin-Yu, Li Yu-Ying, Huang Hai-Xin, Zhao Chen-Chen, Lei Xiao-Xiao, Zhao Bao-Peng, Lu Jing-Yi, Lan Tian, Sun Wen-Chao
Institute of Virology, Wenzhou University, Wenzhou, China.
College of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Front Microbiol. 2023 Oct 6;14:1235620. doi: 10.3389/fmicb.2023.1235620. eCollection 2023.
Seneca Valley virus (SVV), a member of the family, may cause serious water blister diseases in pregnant sows and acute death in newborn piglets, which have resulted in economic losses in pig production. The 3C protease is a vital enzyme for SVV maturation and is capable of regulating protein cleavage and RNA replication of the virus. Additionally, this protease can impede the host's innate immune response by targeting the interferon pathway's principal factor and enhance virus replication by modulating the host's RNA metabolism while simultaneously triggering programmed cell death. This article reviews recent studies on SVV 3C functions, which include viral replication promotion, cell apoptosis modulation and host immune response evasion, and provides a theoretical basis for research on preventing and controlling SVV infection.
塞内卡山谷病毒（SVV）是该病毒科的成员之一，可导致怀孕母猪出现严重水疱病，并导致新生仔猪急性死亡，这已给养猪生产造成经济损失。3C蛋白酶是SVV成熟的关键酶，能够调节病毒的蛋白质切割和RNA复制。此外，这种蛋白酶可通过靶向干扰素途径的主要因子来阻碍宿主的先天免疫反应，并通过调节宿主的RNA代谢来增强病毒复制，同时引发程序性细胞死亡。本文综述了关于SVV 3C功能的最新研究，这些功能包括促进病毒复制、调节细胞凋亡和逃避宿主免疫反应，为防控SVV感染的研究提供了理论依据。
