Adegboye Oluwatobi, Adams Saleigh
Faculty of Biology, Medicine, and Health, The University of Manchester, United Kingdom.
Division of Plastic, Reconstructive and Maxillo-Facial Surgery, The University of Cape Town, South Africa.
JPRAS Open. 2023 Oct 4;38:124-128. doi: 10.1016/j.jpra.2023.10.003. eCollection 2023 Dec.
Scar formation and management is one of the major issues in plastic surgery. Scars are a chronic burden to patients, their families, and the wider healthcare system and while non-surgical and surgical options have been shown to reduce scarring and its impact, there are currently no therapeutic options to completely heal scars or to avoid scarring. Early gestation animals have been reported to heal skin wounds without scarring.
We report on a premature, underweight-for-age neonate of 30 weeks' gestation that suffered a combination of deep partial thickness abrasions and full thickness wounds following birth trauma, who eventually healed with minimal skin scarring.
This case highlights that more research is needed to understand the mechanism and timelines of foetal skin healing, so the knowledge can be used to develop better therapeutic options to treat skin scars in adults.
瘢痕形成与处理是整形手术中的主要问题之一。瘢痕给患者及其家庭以及更广泛的医疗保健系统带来长期负担，虽然非手术和手术方法已被证明可减少瘢痕形成及其影响，但目前尚无完全治愈瘢痕或避免瘢痕形成的治疗方法。据报道，妊娠早期动物的皮肤伤口愈合后无瘢痕形成。
我们报告了一名孕30周的早产、年龄别体重低的新生儿，出生时因创伤导致深部部分厚度擦伤和全层伤口，最终愈合后皮肤瘢痕极小。
本病例表明，需要更多研究来了解胎儿皮肤愈合的机制和时间线，以便将这些知识用于开发更好的治疗方法来治疗成人皮肤瘢痕。
