评估裸盖菇素治疗抑郁障碍的潜力。
Assessing potential of psilocybin for depressive disorders.
机构信息
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
出版信息
Expert Opin Investig Drugs. 2023 Jul-Dec;32(10):887-900. doi: 10.1080/13543784.2023.2273493. Epub 2023 Nov 6.
INTRODUCTION
There has been increasing interest in the role psilocybin may play in the treatment of depressive disorders. Several clinical trials have shown psilocybin to have efficacy in reducing symptoms of depression.
AREASCOVERED
We discuss the current understanding of psilocybin's therapeutic mechanism of action and review existing clinical data investigating psilocybin as a novel therapeutic agent for the treatment of depression.
EXPERT OPINION
There is still much unknown regarding the risks of psilocybin treatment. When weighing the known risks and benefits of psilocybin treatment against those found in existing standards of care, among patients with depression, patients with treatment-resistant depression (TRD) may be the most suitable candidates for psilocybin treatment at this time.
简介
人们对迷幻蘑菇在治疗抑郁障碍方面可能发挥的作用越来越感兴趣。几项临床试验表明，迷幻蘑菇在减轻抑郁症状方面具有疗效。
涵盖领域
我们讨论了目前对迷幻蘑菇治疗作用机制的理解，并回顾了现有的临床数据，这些数据调查了迷幻蘑菇作为一种治疗抑郁症的新型治疗剂的效果。
专家意见
目前，迷幻蘑菇治疗的风险仍有许多未知因素。在权衡迷幻蘑菇治疗的已知风险和益处与现有治疗标准中的风险和益处时，对于抑郁症患者来说，治疗抵抗性抑郁症（TRD）患者可能是目前最适合迷幻蘑菇治疗的患者群体。
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