NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China.
Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin 300134, China.
ACS Appl Mater Interfaces. 2023 Nov 1;15(43):49974-49987. doi: 10.1021/acsami.3c09182. Epub 2023 Oct 23.
Persistent bacterial infections and excessive oxidative stress prevent the healing of diabetic ulcers, leading to an increased disability rate. Current treatments fail to kill bacteria while simultaneously relieving oxidative stress. Herein, a dynamic microenvironment-adaptable hydrogel (BP@CAu) with photothermal performance and reactive oxygen species scavenging is presented for diabetic ulcer healing. This hydrogel prepared using a dynamic borate-ester could respond to acidity in the infection microenvironment for a controllable drug release. An excellent photothermal conversion effect was integrated in the hydrogel, which exhibited strong antibacterial activity against and . The hydrogel attenuated intracellular oxidative stress and inflammation and promoted cell migration. In a full-thickness skin defect model of diabetic rats, the BP@CAu hydrogel contributed to the fastest wound closure, with ideal reepithelialization, granulation tissue formation, and regeneration of blood vessels. Further mechanistic studies revealed that the hydrogel relieved oxidative stress and downregulated the expression of inflammatory cytokines, resulting in dramatic therapeutic effects on diabetic wounds. Therefore, this study provides a synergistic therapeutic strategy for efficient photothermal performance and reactive oxygen species scavenging in diabetic ulcers.
持续性细菌感染和过度的氧化应激会阻碍糖尿病溃疡的愈合，导致残疾率增加。目前的治疗方法无法同时杀死细菌并缓解氧化应激。本文提出了一种具有光热性能和活性氧清除能力的动态微环境适应水凝胶（BP@CAu），用于治疗糖尿病溃疡。该水凝胶是使用动态硼酸酯制备的，可以响应感染微环境中的酸度，实现可控的药物释放。水凝胶中集成了优异的光热转换效果，对 和 具有很强的抗菌活性。水凝胶减轻了细胞内氧化应激和炎症，并促进了细胞迁移。在糖尿病大鼠全层皮肤缺损模型中，BP@CAu 水凝胶促进了最快的伤口闭合，具有理想的上皮化、肉芽组织形成和血管再生。进一步的机制研究表明，水凝胶缓解了氧化应激并下调了炎症细胞因子的表达，从而对糖尿病伤口产生了显著的治疗效果。因此，本研究为糖尿病溃疡的高效光热性能和活性氧清除提供了协同治疗策略。
