Department of Radiation Oncology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Department of Radiation Oncology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China; Graduate School, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Pract Radiat Oncol. 2024 Mar-Apr;14(2):e87-e96. doi: 10.1016/j.prro.2023.10.003. Epub 2023 Oct 21.
Voluntary deep inspiration breath-hold (DIBH) is commonly used in radiation therapy (RT), but the short duration of a single breath-hold, estimated to be around 20 to 40 seconds, is a limitation. This prospective study aimed to assess the feasibility and safety of using a simple preoxygenation technique with a Venturi mask to prolong voluntary DIBH.
The study included 33 healthy volunteers and 21 RT patients. Preoxygenation was performed using a Venturi mask with a 50% oxygen concentration. Paired t tests compared the duration of a single DIBH in room air and after 5, 15, and 30 minutes of preoxygenation in healthy volunteers. Sustainability of breath-hold and tolerability of heart rate and blood pressure were assessed for multiple DIBH durations in both volunteers and patients.
In healthy volunteers, a 15-minute preoxygenation significantly prolonged the duration of a single DIBH by 24.95 seconds compared with 5-minute preoxygenation (89 ± 27.76 vs 113.95 ± 30.63 seconds; P < .001); although there was a statistically significant increase in DIBH duration after 30-minute preoxygenation, it was only extended by 4.95 seconds compared with 15-minute preoxygenation (113.95 ± 30.63 vs 118.9 ± 29.77 seconds; P < .01). After 15-minute preoxygenation, a single DIBH lasted over 100 seconds in healthy volunteers and over 80 seconds in RT patients, with no significant differences among 6 consecutive cycles of DIBH. Furthermore, there were no significant differences in heart rate or blood pressure after DIBHs, including DIBH in room air and 6 consecutive DIBHs after 15-minute preoxygenation (all P > .05).
Preoxygenation with a 50% oxygen concentration for 15 minutes effectively prolongs the duration of 6 cycles of DIBH both in healthy volunteers and RT patients. The utilization of a Venturi mask to deliver 50% oxygen concentration provides a solution characterized by its convenience, good tolerability, and effectiveness.
自愿性深吸气屏气（DIBH）常用于放射治疗（RT）中，但单次屏气的持续时间较短，约为 20 至 40 秒，这是一个限制。本前瞻性研究旨在评估使用带有文丘里面罩的简单预充氧技术延长自愿性 DIBH 的可行性和安全性。
该研究纳入了 33 名健康志愿者和 21 名 RT 患者。使用 50%浓度氧气的文丘里面罩进行预充氧。在健康志愿者中，通过配对 t 检验比较了在室气中和预充氧 5、15 和 30 分钟后单次 DIBH 的持续时间。在志愿者和患者中，评估了多次 DIBH 持续时间下的屏气可持续性和心率及血压的耐受性。
在健康志愿者中，与预充氧 5 分钟相比，15 分钟预充氧可使单次 DIBH 的持续时间显著延长 24.95 秒（89 ± 27.76 秒与 113.95 ± 30.63 秒；P <.001）；虽然 30 分钟预充氧后 DIBH 持续时间有统计学显著增加，但与 15 分钟预充氧相比仅延长 4.95 秒（113.95 ± 30.63 秒与 118.9 ± 29.77 秒；P <.01）。在 15 分钟预充氧后，健康志愿者单次 DIBH 持续时间超过 100 秒，RT 患者超过 80 秒，6 个连续 DIBH 之间无显著差异。此外，DIBH 后心率或血压无显著差异，包括室气中的 DIBH 和 15 分钟预充氧后 6 个连续 DIBH（均 P >.05）。
在健康志愿者和 RT 患者中，使用 50%浓度氧气预充氧 15 分钟可有效延长 6 个周期的 DIBH 持续时间。使用带有文丘里面罩输送 50%氧气浓度的方法具有方便、良好耐受性和有效性的特点。
