Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan.
Department of Public Health, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Hypertens Res. 2024 Mar;47(3):672-676. doi: 10.1038/s41440-023-01476-8. Epub 2023 Oct 23.
This cross-sectional study investigated the association between the estimated glomerular filtration rate (eGFR), a measure of chronic kidney disease (CKD), and cognitive impairment. We used data from 6215 Japanese individuals registered in the Suita Study. Cognitive impairment was defined as a Mini-Mental State Examination (MMSE) score of ≤ 26. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) of cognitive impairment for eGFR 45-59.9 and < 45 mL/min/1.73 m (mild and moderate-to-severe eGFR reductions) compared to eGFR ≥ 60 mL/min/1.73 m (normal eGFR). The results showed that both mild and moderate-to-severe eGFR reductions were associated with cognitive impairment: ORs (95% CIs) = 1.49 (1.22-1.83) and 2.35 (1.69-3.26), respectively (p-trend < 0.001). Each increment of eGFR by 10 mL/min/1.73m was associated with 4.8% lower odds of cognitive impairment. In conclusion, eGFR reduction was associated with cognitive impairment. Managing CKD is essential for preventing cognitive impairment.
这项横断面研究调查了估算肾小球滤过率（eGFR），即慢性肾脏病（CKD）的衡量标准，与认知障碍之间的关联。我们使用了来自注册于吹田研究的 6215 名日本个体的数据。认知障碍的定义为简易精神状态检查（MMSE）评分≤26 分。我们使用逻辑回归计算了 eGFR 45-59.9 和 <45mL/min/1.73m（轻度和中重度 eGFR 降低）与 eGFR≥60mL/min/1.73m（正常 eGFR）相比，认知障碍的优势比（OR）和 95%置信区间（95%CI）。结果表明，轻度和中重度 eGFR 降低均与认知障碍相关：OR（95%CI）=1.49（1.22-1.83）和 2.35（1.69-3.26），差异均有统计学意义（p 趋势<0.001）。eGFR 每增加 10mL/min/1.73m，认知障碍的可能性就会降低 4.8%。总之，eGFR 降低与认知障碍相关。管理 CKD 对于预防认知障碍至关重要。
