An Ji-Ren, Wang Qing-Feng, Sun Gui-Yan, Su Jia-Nan, Liu Jun-Tong, Zhang Chi, Wang Li, Teng Dan, Yang Yu-Feng, Shi Yan
Liaoning Key Laboratory of Chinese Medicine Combining Disease and Syndrome of Diabetes, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People's Republic of China.
College of Integrative Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050200, People's Republic of China.
Diabetes Metab Syndr Obes. 2023 Oct 18;16:3235-3247. doi: 10.2147/DMSO.S432858. eCollection 2023.
It is well documented that diabetes mellitus (DM) is strongly associated with cognitive decline and structural damage to the brain. Cognitive deficits appear early in DM and continue to worsen as the disease progresses, possibly due to different underlying mechanisms. Normal iron metabolism is necessary to maintain normal physiological functions of the brain, but iron deposition is one of the causes of some neurodegenerative diseases. Increasing evidence shows that iron overload not only increases the risk of DM, but also contributes to the development of cognitive impairment. The current review highlights the role of iron overload in diabetic cognitive impairment (DCI), including the specific location and regulation mechanism of iron deposition in the diabetic brain, the factors that trigger iron deposition, and the consequences of iron deposition. Finally, we also discuss possible therapies to improve DCI and brain iron deposition.
有充分的文献记载，糖尿病（DM）与认知能力下降和大脑结构损伤密切相关。认知缺陷在糖尿病早期就会出现，并随着疾病的进展而持续恶化，这可能是由于不同的潜在机制所致。正常的铁代谢对于维持大脑的正常生理功能是必要的，但铁沉积是一些神经退行性疾病的病因之一。越来越多的证据表明，铁过载不仅会增加患糖尿病的风险，还会导致认知障碍的发展。本综述重点介绍了铁过载在糖尿病认知障碍（DCI）中的作用，包括糖尿病大脑中铁沉积的具体位置和调节机制、触发铁沉积的因素以及铁沉积的后果。最后，我们还讨论了改善糖尿病认知障碍和大脑铁沉积的可能疗法。
