腹膜透析患者第一年残余肾功能下降率与死亡率的关系。
The relationship between decline rate of residual renal function in the first year and mortality in peritoneal dialysis patients.
机构信息
Department of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Department of Nephrology and Rheumatology, The First Hospital of Changsha, Changsha, China.
出版信息
Ther Apher Dial. 2024 Apr;28(2):255-264. doi: 10.1111/1744-9987.14075. Epub 2023 Oct 24.
INTRODUCTION
To assess the relationship between the rate of residual renal function (RRF) decline in the first year and all-cause and cardiovascular mortality in peritoneal dialysis (PD) patients.
METHODS
Incident PD patients were divided into two groups by the corresponding RRF decline value, when hazard ratio (HR) = 1 was found by the restricted cubic spline. The associations of rate of decline of RRF in the first year with mortality were evaluated.
RESULTS
Of 497 PD patients, 122 patients died. After adjusting for confounding factors, patients in fast-decline group had a significant increase risk of all-cause and cardiovascular mortality (HR: 1.97 and 2.09, respectively). Each 0.1-mL/min/1.73 m /month decrease in RRF in the first year of PD was associated with a 19% and 20% higher risk of all-cause and cardiovascular mortality, respectively.
CONCLUSIONS
Faster decline of RRF in the first year was independently associated with all-cause and cardiovascular mortality in PD patients.
简介
评估腹膜透析（PD）患者第一年残余肾功能（RRF）下降率与全因和心血管死亡率之间的关系。
方法
根据风险比（HR）= 1 时的限制立方样条，将发生 PD 的患者分为两组，相应的 RRF 下降值。评估第一年 RRF 下降率与死亡率的相关性。
结果
在 497 名 PD 患者中，有 122 名患者死亡。调整混杂因素后，快速下降组患者全因和心血管死亡率显著升高（HR：1.97 和 2.09）。PD 后第一年 RRF 每下降 0.1-mL/min/1.73m2/月，全因和心血管死亡率分别增加 19%和 20%。
结论
RRF 在第一年的快速下降与 PD 患者的全因和心血管死亡率独立相关。
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