Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
Eur J Immunol. 2024 Jan;54(1):e2350422. doi: 10.1002/eji.202350422. Epub 2023 Nov 9.
Utilizing an autoimmune bone marrow chimera model we determined that B cells depend critically on MHCII expression for participation in the germinal center, but cells displaying a 50% reduction in surface MHCII compete efficiently with their wild-type counterparts. This provides insights into the requirements for germinal center participation.
利用自身免疫性骨髓嵌合体模型，我们确定 B 细胞对于参与生发中心的形成严重依赖于 MHCII 的表达，但表面 MHCII 表达降低 50%的细胞与野生型细胞竞争效率相当。这为了解生发中心参与的要求提供了线索。
