轻度新型冠状病毒肺炎后血液学和血液流变学参数的变化：一项4个月的随访研究
Changes in Hematological and Hemorheological Parameters Following Mild COVID-19: A 4-Month Follow-Up Study.
作者信息
Bros Janina, Ibershoff Lars, Zollmann Emily, Zacher Jonas, Tomschi Fabian, Predel Hans-Georg, Bloch Wilhelm, Grau Marijke
机构信息
Institute of Cardiovascular Research and Sports Medicine, Molecular and Cellular Sports Medicine, German Sport University Cologne, 50933 Cologne, Germany.
Department of Preventive and Rehabilitative Sports and Performance Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, 50933 Cologne, Germany.
出版信息
Hematol Rep. 2023 Oct 10;15(4):543-554. doi: 10.3390/hematolrep15040057.
BACKGROUND
Coronavirus Disease 2019 (COVID-19) was described to affect red blood cells (RBC) in both severe and mild disease courses. The aim of this study was to investigate whether hematological and hemorheological changes that were previously described for COVID-19 patients after the acute infection state are still prominent after another 4 months to assess potential long-term effects.
METHODS
Hematological and RBC rheological parameters, including deformability and aggregation, were measured 41 days after infection in COVID-19 patients and non-COVID control (T0) and 4 months later in COVID-19 patients (T1).
RESULTS
The data confirm alterations in hematological parameters, mainly related to cell volume and hemoglobin concentration, but also reduced deformability and increased aggregation at T0 compared to control. While RBC deformability seems to have recovered, hemoglobin-related parameters and RBC aggregation were still impaired at T1. The changes were thus more pronounced in male COVID-19 patients.
CONCLUSION
COVID-19-related changes of the RBC partly consist of several months and might be related to persistent symptoms reported by many COVID-19 patients.
背景
2019冠状病毒病（COVID-19）在重症和轻症病程中均被描述为会影响红细胞（RBC）。本研究的目的是调查急性感染状态后曾被描述的COVID-19患者的血液学和血液流变学变化在4个月后是否仍然显著，以评估潜在的长期影响。
方法
在COVID-19患者感染后41天（T0）及非COVID对照组测量血液学和红细胞流变学参数，包括变形性和聚集性，并在4个月后对COVID-19患者再次测量（T1）。
结果
数据证实了血液学参数的改变，主要与细胞体积和血红蛋白浓度有关，与对照组相比，在T0时红细胞变形性降低且聚集性增加。虽然红细胞变形性似乎已恢复，但在T1时血红蛋白相关参数和红细胞聚集性仍受损。这些变化在男性COVID-19患者中更为明显。
结论
COVID-19相关的红细胞变化部分持续数月，可能与许多COVID-19患者报告的持续症状有关。
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