Gupta Rajesh K, Reddy Thejasvi A, Gupta Ashutosh, Samant Rohan, Perez Carlos A, Haque Anam
Division of Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Texas Health Science Center, Houston, TX 77030, USA.
McGovern Medical School, UT Health Science Center, Houston, TX 77030, USA.
Neurol Int. 2023 Sep 26;15(4):1200-1211. doi: 10.3390/neurolint15040075.
Ecchordosis physaliphora (EP) is a benign notochordal remnant, which is often an incidental finding; however, it can rarely present with neurological symptoms. We performed a systematic review of the literature for cases of symptomatic EP published in PubMed, Web of Science and Embase from January 1982 to May 2023. This is the largest review to date and revealed 60 cases including ours. Headache (55%) and CSF rhinorrhea (32%) were the most frequent clinical manifestations. The majority of symptomatic EP lesions were located in the prepontine region (77%) and required surgical resection (75%). EP should be considered in patients with neurologic symptoms in the setting of prepontine or posterior sphenoid sinus lesions. While symptomatic patients often require surgical intervention, rare cases may respond to oral corticosteroids.
泡状脊索瘤（EP）是一种良性的脊索残余物，通常是偶然发现；然而，它很少会出现神经症状。我们对1982年1月至2023年5月在PubMed、科学网和Embase上发表的有症状EP病例的文献进行了系统综述。这是迄今为止最大规模的综述，共纳入60例病例，包括我们的病例。头痛（55%）和脑脊液鼻漏（32%）是最常见的临床表现。大多数有症状的EP病变位于脑桥前区（77%），需要手术切除（75%）。对于脑桥前或蝶窦后部病变伴有神经症状的患者，应考虑EP。虽然有症状的患者通常需要手术干预，但罕见病例可能对口服糖皮质激素有反应。
