Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, 72079, USA.
Toxicologic Pathology Associates, Inc., National Center for Toxicological Research, Jefferson, AR, 72079, USA.
Arch Toxicol. 2024 Jan;98(1):335-345. doi: 10.1007/s00204-023-03613-1. Epub 2023 Oct 24.
Triclosan is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Due to its extensive use, there is potential for humans in all age groups to receive lifetime exposures to triclosan, yet data on the chronic dermal toxicity/carcinogenicity of triclosan are still lacking. We evaluated the toxicity/carcinogenicity of triclosan administered dermally to B6C3F1 mice for 104 weeks. Groups of 48 male and 48 female B6C3F1 mice received dermal applications of 0, 1.25, 2.7, 5.8, or 12.5 mg triclosan/kg body weight (bw)/day in 95% ethanol, 7 days/week for 104 weeks. Vehicle control animals received 95% ethanol only; untreated, naïve control mice did not receive any treatment. There were no significant differences in survival among the groups. The highest dose of triclosan significantly decreased the body weight of mice in both sexes, but the decrease was ≤ 9%. Minimal-to-mild epidermal hyperplasia, suppurative inflammation (males only), and ulceration (males only) were observed at the application site in the treated groups, with the highest incidence occurring in the 12.5 mg triclosan/kg bw/day group. No tumors were identified at the application site. Female mice had a positive trend in the incidence of pancreatic islet adenoma. In male mice, there were positive trends in the incidences of hepatocellular carcinoma and hepatocellular adenoma or carcinoma (combined), with the increase of carcinoma being significant in the 5.8 and 12.5 mg/kg/day groups and the increase in hepatocellular adenoma or carcinoma (combined) being significant in the 2.7, 5.8, and 12.5 mg/kg/day groups.
三氯生是一种广泛应用于个人护理产品、家庭用品、医疗器械和临床环境中的抗菌剂。由于其广泛使用，所有年龄段的人群都有可能在一生中接触到三氯生，但关于三氯生的慢性皮肤毒性/致癌性的数据仍然缺乏。我们评估了经皮给予 B6C3F1 小鼠三氯生的毒性/致癌性，为期 104 周。48 只雄性和 48 只雌性 B6C3F1 小鼠接受经皮应用 0、1.25、2.7、5.8 或 12.5mg/kg 体重（bw）/天的三氯生，每日 7 天，共 104 周。载体对照组动物仅接受 95%乙醇；未处理的、未处理的对照小鼠未接受任何治疗。各组动物的存活率无显著差异。最高剂量的三氯生显著降低了雌雄小鼠的体重，但降幅≤9%。在处理组中，应用部位观察到轻微至中度的表皮增生、化脓性炎症（仅雄性）和溃疡（仅雄性），最高发生率发生在 12.5mg/kg bw/天组。在应用部位未发现肿瘤。雌性小鼠胰腺胰岛腺瘤的发生率呈阳性趋势。在雄性小鼠中，肝细胞癌和肝细胞腺瘤或癌（合并）的发生率呈阳性趋势，5.8 和 12.5mg/kg/天组的癌发生率显著增加，2.7、5.8 和 12.5mg/kg/天组的肝细胞腺瘤或癌（合并）发生率显著增加。
