母亲在怀孕期间接种 mRNA COVID-19 疫苗对 2022 年 3 月 9 日至 2023 年 5 月 31 日期间，在 SARS-CoV-2 奥密克戎流行期间 6 月龄以下婴儿因 COVID-19 相关住院的有效性-20 个州。
Effectiveness of Maternal mRNA COVID-19 Vaccination During Pregnancy Against COVID-19-Associated Hospitalizations in Infants Aged <6 Months During SARS-CoV-2 Omicron Predominance - 20 States, March 9, 2022-May 31, 2023.
出版信息
MMWR Morb Mortal Wkly Rep. 2023 Sep 29;72(39):1057-1064. doi: 10.15585/mmwr.mm7239a3.
Infants aged <6 months are not eligible for COVID-19 vaccination. Vaccination during pregnancy has been associated with protection against infant COVID-19-related hospitalization. The Overcoming COVID-19 Network conducted a case-control study during March 9, 2022-May 31, 2023, to evaluate the effectiveness of maternal receipt of a COVID-19 vaccine dose (vaccine effectiveness [VE]) during pregnancy against COVID-19-related hospitalization in infants aged <6 months and a subset of infants aged <3 months. VE was calculated as (1 - adjusted odds ratio) x 100% among all infants aged <6 months and <3 months. Case-patients (infants hospitalized for COVID-19 outside of birth hospitalization and who had a positive SARS-CoV-2 test result) and control patients (infants hospitalized for COVID-19-like illness with a negative SARS-CoV-2 test result) were compared. Odds ratios were determined using multivariable logistic regression, comparing the odds of receipt of a maternal COVID-19 vaccine dose (completion of a 2-dose vaccination series or a third or higher dose) during pregnancy with maternal nonvaccination between case- and control patients. VE of maternal vaccination during pregnancy against COVID-19-related hospitalization was 35% (95% CI = 15%-51%) among infants aged <6 months and 54% (95% CI = 32%-68%) among infants aged <3 months. Intensive care unit admissions occurred in 23% of all case-patients, and invasive mechanical ventilation was more common among infants of unvaccinated (9%) compared with vaccinated mothers (1%) (p = 0.02). Maternal vaccination during pregnancy provides some protection against COVID-19-related hospitalizations among infants, particularly those aged <3 months. Expectant mothers should remain current with COVID-19 vaccination to protect themselves and their infants from hospitalization and severe outcomes associated with COVID-19.
<6 月龄婴儿不符合 COVID-19 疫苗接种条件。妊娠期接种疫苗与预防婴儿 COVID-19 相关住院有关。克服 COVID-19 网络于 2022 年 3 月 9 日至 2023 年 5 月 31 日期间进行了一项病例对照研究，以评估孕妇在妊娠期接种一剂 COVID-19 疫苗（疫苗有效性 [VE]）对 <6 月龄和 <3 月龄婴儿 COVID-19 相关住院的有效性。VE 在所有 <6 月龄和 <3 月龄婴儿中计算为（1-调整后的优势比）x100%。病例患者（COVID-19 住院治疗且 SARS-CoV-2 检测结果为阳性的婴儿）和对照患者（COVID-19 样疾病住院治疗且 SARS-CoV-2 检测结果为阴性的婴儿）进行比较。使用多变量逻辑回归确定优势比，比较病例患者和对照患者之间孕妇在妊娠期接受 COVID-19 疫苗剂量（完成 2 剂疫苗接种系列或第 3 剂或更高剂量）与母亲未接种疫苗的几率。妊娠期母亲接种疫苗对 <6 月龄婴儿 COVID-19 相关住院的 VE 为 35%（95%CI=15%-51%），<3 月龄婴儿为 54%（95%CI=32%-68%）。所有病例患者中有 23%入住重症监护病房，未接种疫苗（9%）的婴儿比接种疫苗（1%）的母亲更常见需要侵入性机械通气（p=0.02）。妊娠期母亲接种疫苗可为婴儿提供一些针对 COVID-19 相关住院的保护，尤其是 <3 月龄的婴儿。孕妇应及时接种 COVID-19 疫苗，以保护自己和婴儿免受 COVID-19 相关住院和严重后果的影响。
Zotero 插件