Khoptynskaia S K, Kolesnikova A I, Shishkin I P, Baĭsogolov G D, Konopliannikov A G
Ter Arkh. 1986;58(9):50-2.
Monolayer cultivation of the radiated bone marrow was performed in 39 lymphogranulomatosis patients with a long-term remission attained after radiotherapy according to the radical program. In 41 patients, the non-radiated bone marrow was also subjected to monolayer cultivation. Counts were made of the total number of myelokaryocytes and myelogram. Analysis of the punctates from the radiated areas has shown that the growth of fibroblast colonies occurred where complete or partial recovery of the cellularity was detected and the total focal dose per bone marrow was less than 35 Gy. With the use of large doses the growth of the colonies was detected in none of the cases. In the radiated areas, the patients commonly manifested bone marrow aplasia. Investigation of the punctates from intact areas pointed to the growth of the colonies in the majority of cases whereas the myelogram count to the increased percentage of the reticular cells, lymphoid and erythroid elements.
对39例根据根治性方案放疗后获得长期缓解的淋巴肉芽肿病患者进行了照射骨髓的单层培养。对41例患者的未照射骨髓也进行了单层培养。对骨髓细胞总数和骨髓象进行了计数。对照射区域穿刺物的分析表明，在检测到细胞数量完全或部分恢复且每个骨髓的总局部剂量小于35 Gy的部位，成纤维细胞集落生长。使用大剂量时，在所有病例中均未检测到集落生长。在照射区域，患者通常表现为骨髓发育不全。对完整区域穿刺物的研究表明，在大多数病例中集落生长，而骨髓象计数显示网状细胞、淋巴细胞和红细胞成分的百分比增加。
