Jacques-Aviñó Constanza, Alarcón Guitiérrez Miguel, Barbera María Jesús, Fuertes Irene, Martin-Ezquerra Gemma, Lopez-Contreras Joaquín, Vives Álvaro, Rodriguez Raquel, Ros Miriam, Rius Cristina, de Olalla Patricia Garcia
Servei d'Epidemiologia, Agència de Salut Pública de Barcelona, Barcelona, Spain.
Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Gran Via Corts Catalanes, 587, àtic, 08007, Barcelona, Spain.
Arch Sex Behav. 2024 Feb;53(2):735-744. doi: 10.1007/s10508-023-02711-6. Epub 2023 Oct 24.
In the last few years, the frequency of sexually transmitted infections (STI) has increased, as has the number of people with multiple infections. The aim of our study was to describe the epidemiological characteristics of persons with repeated bacterial STI and to determine the risk factors for these episodes in persons living in Barcelona during the period 2007-2018. We studied all cases of bacterial STI included in the STI registry of Barcelona. Repeated STI were defined as a diagnosis of gonorrhea, syphilis, or lymphogranuloma venereum (LGV) after a first episode of one of these infections. Analysis was stratified by sex and place of birth. The factors associated with time to reinfection were determined by Kaplan-Meier estimates, while the factors associated with risk of infection were determined by a Cox proportional hazards model. Of 9927 persons with a diagnosis of bacterial STI, 1690 (17.0%) had at least two episodes of STI during the study period. On multivariate analysis, repeat STI were independently associated with male sex assigned at birth (HR: 3.45; 95%CI 2.22-5.36), age less than 34 years (HR: 1.22; 95%CI 1.10-1.35); gay, bisexual, and other men who have sex with men, and transgender o transsexual woman (GBSMS/Trans) (HR: 4.03; 95%CI 3.24-5.03), having gonorrhea as first diagnosis (HR:1.49, 95%CI 1.34-1.66) or LGV (HR:1.75; 95%CI 1.47-2.08) and coinfection with HIV (HR:1.98; 95%CI 1.78-2.21). Sexual health programs should be strengthened to prevent STI and reinfection in key populations.
在过去几年中，性传播感染（STI）的发生率有所上升，多重感染的人数也在增加。我们研究的目的是描述反复发生细菌性性传播感染患者的流行病学特征，并确定2007年至2018年期间居住在巴塞罗那的人群中这些感染发作的风险因素。我们研究了巴塞罗那性传播感染登记处记录的所有细菌性性传播感染病例。反复性传播感染被定义为在首次发生淋病、梅毒或性病性淋巴肉芽肿（LGV）感染之一后，再次诊断出这些感染中的一种。分析按性别和出生地进行分层。通过Kaplan-Meier估计确定与再次感染时间相关的因素，而通过Cox比例风险模型确定与感染风险相关的因素。在9927例诊断为细菌性性传播感染的患者中，1690例（17.0%）在研究期间至少有两次性传播感染发作。多变量分析显示，反复性传播感染与出生时被指定为男性（HR：3.45；95%CI 2.22-5.36）、年龄小于34岁（HR：1.22；95%CI 1.10-1.35）、男同性恋、双性恋和其他与男性发生性关系的男性以及变性女性或易性症女性（GBSMS/Trans）（HR：4.03；95%CI 3.24-5.03）、首次诊断为淋病（HR：1.49，95%CI 1.34-1.66）或LGV（HR：1.75；95%CI 1.47-2.08）以及合并感染HIV（HR：1.98；95%CI 1.78-2.21）独立相关。应加强性健康项目，以预防关键人群中的性传播感染和再次感染。
