Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
School of Public Health, Department of Health Care Administration and Policy, University of Nevada Las Vegas(UNLV), Las Vegas, NV, USA.
BMC Surg. 2023 Oct 24;23(1):324. doi: 10.1186/s12893-023-02236-8.
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. The survival rate after hepatectomy as the first line of treatment for HCC depends on various factors. This study evaluated the association of the ABO blood group and Rh with overall survival (OS) and Recurrence-free survival (RFS) rate after hepatectomy.
This multicenter retrospective cohort study reviewed the medical files of 639 HCC patients who underwent hepatectomy from 2010 to 2022 in three medical centers affiliated with the Iran University of Medical Sciences. Patient data, including demographic, clinical, tumor characteristics, and post-surgery outcomes, were collected by referring to the patient's medical profiles. The Cox proportional hazard investigated the relationship between ABO blood group type and OS and RFS rate after hepatectomy.
The five-year OS and RFS rates were 25.4% and 18.7%, respectively. The five-year OS (Lok rank:40.89, P:0.001) and RFS rate in patients with blood type A were significantly lower than in non-A patients. (Lok rank:10.8, P:0.001) The multivariate Cox analysis showed that blood type A, age < 45 years, tumor size > 5 cm, Poor tumor differentiation, presence of metastasis, The number of involved lymph nodes ≤ 2, and serum Alpha-Fetoprotein)AFP( level ≥ 400 were significantly related to the decreased survival rate of HCC patients after hepatectomy (P < 0.05) There was no significant association between Rh with OS and RFS (P > 0.05).
Blood group type A, compared to non-A, can be associated with decreased OS and RFS rates in patients with HCC after hepatectomy.
肝细胞癌（HCC）是全球最常见的恶性肿瘤之一。肝癌切除术作为 HCC 的一线治疗方法的存活率取决于多种因素。本研究评估了 ABO 血型和 Rh 与肝癌切除术后总生存率（OS）和无复发生存率（RFS）的关系。
这是一项多中心回顾性队列研究，回顾了 2010 年至 2022 年期间在隶属于伊朗医科大学的三个医疗中心接受肝癌切除术的 639 名 HCC 患者的病历。通过查阅患者的病历，收集了患者数据，包括人口统计学、临床、肿瘤特征和手术后结果。Cox 比例风险模型研究了 ABO 血型类型与肝癌切除术后 OS 和 RFS 率之间的关系。
五年 OS 和 RFS 率分别为 25.4%和 18.7%。A 型血患者的五年 OS（Lok 秩：40.89，P：0.001）和 RFS 率明显低于非 A 型血患者。（Lok 秩：10.8，P：0.001）多变量 Cox 分析表明，A 型血、年龄<45 岁、肿瘤大小>5cm、肿瘤分化差、存在转移、受累淋巴结数≤2 个、血清甲胎蛋白（AFP）水平≥400ng/ml 与肝癌切除术后 HCC 患者生存率降低显著相关（P<0.05）。Rh 与 OS 和 RFS 无显著相关性（P>0.05）。
与非 A 型血相比，A 型血与肝癌切除术后 HCC 患者的 OS 和 RFS 率降低相关。
