基于地中海饮食的代谢组学评分与老年人认知能力下降：三城队列研究中的巢式病例对照分析。

A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case-Control Analysis Nested within the Three-City Cohort Study.

机构信息

Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, Food Science and Nutrition Torribera Campus, University of Barcelona, Santa Coloma de Gramenet, 08921, Spain.

Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.

出版信息

Mol Nutr Food Res. 2024 Jul;68(13):e2300271. doi: 10.1002/mnfr.202300271. Epub 2023 Oct 24.

DOI:10.1002/mnfr.202300271

PMID:37876144

Abstract

SCOPE

Evidence on the Mediterranean diet (MD) and age-related cognitive decline (CD) is still inconclusive partly due to self-reported dietary assessment. The aim of the current study is to develop an MD- metabolomic score (MDMS) and investigate its association with CD in community-dwelling older adults.

METHODS AND RESULTS

This study includes participants from the Three-City Study from the Bordeaux (n = 418) and Dijon (n = 422) cohorts who are free of dementia at baseline. Repeated measures of cognition over 12 years are collected. An MDMS is designed based on serum biomarkers related to MD key food groups and using a targeted metabolomics platform. Associations with CD are investigated through conditional logistic regression (matched on age, sex, and education level) in both sample sets. The MDMS is found to be inversely associated with CD (odds ratio [OR] [95% confidence interval (CI)] = 0.90 [0.80-1.00]; p = 0.048) in the Bordeaux (discovery) cohort. Results are comparable in the Dijon (validation) cohort, with a trend toward significance (OR [95% CI] = 0.91 [0.83-1.01]; p = 0.084).

CONCLUSIONS

A greater adherence to the MD, here assessed by a serum MDMS, is associated with lower odds of CD in older adults.

摘要

范围

地中海饮食（MD）和与年龄相关的认知衰退（CD）的证据仍然不确定，部分原因是自我报告的饮食评估。本研究的目的是开发一种 MD-代谢组学评分（MDMS），并调查其与社区居住的老年人 CD 的相关性。

方法和结果

本研究包括来自波尔多（n=418）和第戎（n=422）队列的三城研究参与者，他们在基线时没有痴呆症。在 12 年内对认知进行了多次重复测量。根据与 MD 关键食物组相关的血清生物标志物，使用靶向代谢组学平台设计了 MDMS。通过条件逻辑回归（在年龄、性别和教育水平上匹配）在两个样本集中调查与 CD 的关联。发现 MDMS 与 CD 呈负相关（比值比[OR] [95%置信区间（CI）] = 0.90 [0.80-1.00]；p = 0.048）在波尔多（发现）队列中。在第戎（验证）队列中的结果相当，具有显著趋势（OR [95% CI] = 0.91 [0.83-1.01]；p = 0.084）。