La Fe University and Polytechnic Hospital, Valencia, Spain.
Rom J Ophthalmol. 2023 Jul-Sep;67(3):305-308. doi: 10.22336/rjo.2023.49.
Description of melphalan's toxicity in retinoblastoma treatment. Clinical case report. We presented a case of unilateral retinoblastoma with vitreous seeding at diagnosis, in which the use of intravitreal melphalan produced many adverse reactions. Vitreous seedings have been one of the most important challenges in retinoblastoma treatment. Intravitreal melphalan has achieved the regression of vitreous seedings in a large percentage of cases. It is a safe treatment; however, it can produce toxicity, even with the standard dose of 20-30 µg, which has been poorly documented. Exhaustive follow-up of patients is recommended for an early diagnosis of possible adverse effects. OS = left eye, RI = magnetic resonance imaging, OCT = optical coherence tomography.
描述美法仑在视网膜母细胞瘤治疗中的毒性。临床病例报告。我们报告了一例单侧视网膜母细胞瘤在诊断时伴有玻璃体内播散的病例，其中玻璃体内注射美法仑产生了许多不良反应。玻璃体内播散一直是视网膜母细胞瘤治疗中最具挑战性的问题之一。玻璃体内注射美法仑已使很大一部分玻璃体内播散病例得到消退。它是一种安全的治疗方法；然而，即使使用标准剂量 20-30μg，也会产生毒性，而这方面的记录很少。建议对患者进行彻底的随访，以便及早发现可能的不良反应。OS =左眼，RI =磁共振成像，OCT =光学相干断层扫描。
