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Inhibition in vivo of both infective Leishmania major and L. mexicana amazonensis mediated by a single monoclonal antibody.

作者信息

Debons-Guillemin M C, Vouldoukis I, Roseto A, Alfred C, Chopin C, Ploton I, Monjour L

出版信息

Trans R Soc Trop Med Hyg. 1986;80(2):258-60. doi: 10.1016/0035-9203(86)90030-1.

Abstract

Monoclonal antibodies raised against a strain of Leishmania infantum isolated in Greece were produced and tested for their protective effect in an in vivo system (in BALB/C mice). A single monoclonal antibody, IgG2b isotype, can prevent the development of two Leishmania strains in vivo: one of L. major and one of L. mexicana amazonensis. This antibody-mediated protection may be dependent on complement.

摘要

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