妥布霉素与肾缺血。
Tobramycin and renal ischemia.
作者信息
Wilson J A, Hackett R L, Finlayson B
出版信息
Urology. 1986 Nov;28(5):409-12. doi: 10.1016/0090-4295(86)90075-0.
PMID:3787904
Abstract
Sprague-Dawley rats were injected with known nephrotoxic doses of tobramycin and then subjected to varying amounts of warm renal ischemia. Analysis of serum creatinine at the time of sacrifice revealed no statistically significant difference among controls and the two doses of tobramycin at any given duration of ischemia. Light microscopy revealed no worsening of tubular necrosis with increasing doses of tobramycin.
摘要
将已知肾毒性剂量的妥布霉素注射到斯普拉格-道利大鼠体内，然后对其施加不同程度的肾脏热缺血。处死时血清肌酐分析显示，在任何给定的缺血持续时间下，对照组与两种剂量的妥布霉素之间均无统计学上的显著差异。光学显微镜检查显示，随着妥布霉素剂量增加，肾小管坏死并未加重。
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