State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy/Academy for Interdiscipline, Chengdu Univesity of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Biomed Pharmacother. 2023 Dec;168:115634. doi: 10.1016/j.biopha.2023.115634. Epub 2023 Oct 24.
Peripheral arterial disease (PAD) has been historically neglected, which has resulted in a lack of effective drugs in clinical practice. However, with the increasing prevalence of diseases like atherosclerosis and diabetes, the incidence of PAD is rising and cannot be ignored. Researchers are exploring the potential of promoting angiogenesis through exogenous compounds to improve PAD. This paper focuses on the therapeutic effect of natural products (Salidroside, Astragaloside IV, etc.) and synthetic compounds (Cilostazol, Dapagliflozin, etc.). Specifically, it examines how they can promote autocrine secretion of vascular endothelial cells, enhance cell paracrine interactions, and regulate endothelial progenitor cell function. The activation of these effects may be closely related to PI3K, AMPK, and other pathways. Overall, these exogenous compounds have promising therapeutic potential for PAD. This study aims to summarize the potential active compounds, provide a variety of options for the search for drugs for the treatment of PAD, and bring light to the treatment of patients.
外周动脉疾病（PAD）在历史上一直被忽视，这导致临床上缺乏有效的药物。然而，随着动脉粥样硬化和糖尿病等疾病的患病率不断上升，PAD 的发病率也在上升，不容忽视。研究人员正在探索通过外源性化合物促进血管生成以改善 PAD 的潜力。本文重点介绍了天然产物（红景天苷、黄芪甲苷等）和合成化合物（西洛他唑、达格列净等）的治疗作用。具体来说，它研究了它们如何促进血管内皮细胞的自分泌、增强细胞旁分泌相互作用以及调节内皮祖细胞功能。这些作用的激活可能与 PI3K、AMPK 等途径密切相关。总的来说，这些外源性化合物在外周动脉疾病的治疗中具有很大的潜力。本研究旨在总结潜在的活性化合物，为治疗 PAD 的药物寻找提供多种选择，并为患者的治疗带来希望。
