ExCE Research Group, Department of Physical Education, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil.
Exp Gerontol. 2023 Nov;183:112317. doi: 10.1016/j.exger.2023.112317. Epub 2023 Oct 25.
To map out the studies that have investigated the associations of polypharmacy and/or potentially inappropriate medication (PIM) use with physical activity and sedentary time in older adults.
We conducted a literature search from inception to December 2022 in PubMed, Embase, Web of Science, and Scopus.
observational studies including older adults (≥60 years); English, Portuguese, and Spanish languages; any definition of polypharmacy; implicit and explicit criteria of PIM use; physical activity and/or sedentary time data.
Fourteen cross-sectional studies were included; 11 defined polypharmacy as ≥5 medications (prevalence ranging from 9.5 % to 57 %). No study reported information on PIM use. Most studies included participants aged <80 years. Twelve studies included self-reported measures of physical activity, while two studies used accelerometer-measured physical activity. Ten studies included analyses adjusted for confounders, and nine considered polypharmacy as an outcome. All of them demonstrated an inverse association between physical activity and polypharmacy, irrespective of the definition of polypharmacy and the assessment method employed (self-reported or accelerometry). One study reported an inverse association between polypharmacy (as the exposure) and physical activity (as the outcome). None of the studies investigated the association between sedentary time and polypharmacy.
Limited evidence suggests an inverse association between physical activity and polypharmacy in older adults. However, the relationship between PIM use, physical activity, and sedentary time remains unknown. Longitudinal studies utilizing objectively-measured physical activity and sedentary time are needed to better clarify the relationship between these movement behaviors and polypharmacy and/or PIM use in older adults.
绘制研究，以调查老年人中药物使用过多和/或潜在不适当药物（PIM）使用与身体活动和久坐时间之间的关联。
我们从文献开始到 2022 年 12 月在 PubMed、Embase、Web of Science 和 Scopus 进行了文献检索。
包括老年人（≥60 岁）的观察性研究；英语、葡萄牙语和西班牙语；任何药物使用过多的定义；PIM 使用的隐式和显式标准；身体活动和/或久坐时间数据。
共纳入 14 项横断面研究；11 项研究将药物使用过多定义为≥5 种药物（患病率从 9.5%到 57%不等）。没有研究报告关于 PIM 使用的信息。大多数研究纳入的参与者年龄<80 岁。12 项研究包括自我报告的身体活动测量，而两项研究使用加速度计测量身体活动。10 项研究包括对混杂因素进行调整的分析，9 项研究将药物使用过多作为结果进行考虑。所有研究都表明，无论药物使用过多的定义和使用的评估方法（自我报告或加速度计）如何，身体活动与药物使用过多之间存在反比关系。一项研究报告了药物使用过多（作为暴露）与身体活动（作为结果）之间的反比关系。没有研究调查久坐时间与药物使用过多之间的关系。
有限的证据表明，老年人中身体活动与药物使用过多之间存在反比关系。然而，PIM 使用、身体活动和久坐时间之间的关系尚不清楚。需要进行纵向研究，利用客观测量的身体活动和久坐时间，以更好地阐明这些运动行为与老年人中药物使用过多和/或 PIM 使用之间的关系。
