State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontics West China Hospital of Stomatology, Sichuan University, 14# 3rd Section, Renmin South Road, Chengdu, 610041, Sichuan, China.
Mol Cell Biochem. 2024 Oct;479(10):2523-2543. doi: 10.1007/s11010-023-04871-4. Epub 2023 Oct 25.
Ferroptosis is a newly identified form of programmed cell death that is connected to iron-dependent lipid peroxidization. It involves a variety of physiological processes involving iron metabolism, lipid metabolism, oxidative stress, and biosynthesis of nicotinamide adenine dinucleotide phosphate, glutathione, and coenzyme Q10. So far, it has been discovered to contribute to the pathological process of many diseases, such as myocardial infarction, acute kidney injury, atherosclerosis, and so on. Macrophages are innate immune system cells that regulate metabolism, phagocytize pathogens and dead cells, mediate inflammatory reactions, promote tissue repair, etc. Emerging evidence shows strong associations between macrophages and ferroptosis, which can provide us with a deeper comprehension of the pathological process of diseases and new targets for the treatments. In this review, we summarized the crosstalk between macrophages and ferroptosis and anatomized the application of this association in disease treatments, both non-neoplastic and neoplastic diseases. In addition, we have also addressed problems that remain to be investigated, in the hope of inspiring novel therapeutic strategies for diseases.
铁死亡是一种新发现的与铁依赖性脂质过氧化相关的程序性细胞死亡方式。它涉及多种生理过程，包括铁代谢、脂质代谢、氧化应激以及烟酰胺腺嘌呤二核苷酸磷酸、谷胱甘肽和辅酶 Q10 的生物合成。迄今为止，它已被发现与多种疾病的病理过程有关，如心肌梗死、急性肾损伤、动脉粥样硬化等。巨噬细胞是先天免疫系统细胞，可调节代谢、吞噬病原体和死亡细胞、介导炎症反应、促进组织修复等。新出现的证据表明巨噬细胞与铁死亡之间存在强烈关联，这可以为我们深入理解疾病的病理过程和新的治疗靶点提供帮助。在这篇综述中，我们总结了巨噬细胞与铁死亡之间的相互作用，并分析了这种关联在非肿瘤和肿瘤疾病治疗中的应用。此外，我们还讨论了仍需研究的问题，希望为疾病的治疗提供新的策略。
