Wang Shen, Heng Ke, Song Xingchen, Zhai Juan, Zhang Huanyu, Geng Qinghe
Key Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Central Lab, Pizhou Hospital, Xuzhou Medical University, Xuzhou, 221300, China.
Mol Nutr Food Res. 2023 Dec;67(24):e2300330. doi: 10.1002/mnfr.202300330. Epub 2023 Oct 25.
Cellular senescence (CS) is closely related to tissue ageing including bone ageing. CS and the senescence-associated secretory phenotype (SASP) have emerged as critical pathogenesis elements of senile osteoporosis. This study aims to investigate the effect of lycopene on senile osteoporosis.
The senescence-accelerated mouse prone 6 (SAMP6) strain of mice is used as the senile osteoporosis model. Daily ingestion of lycopene for 8 weeks preserves the bone mass, density, strength, and microarchitecture in the SAMP6 mice. Moreover, these alterations are associated with a decrease in oxidative stress in the senile osteoporosis model. In addition, there is a reduction in osteoblast and osteocyte senescence and the SASP in the bone tissues of the SAMP6 mice. Lycopene improves bone health likely due to its antioxidant properties that may be linked with the regulation of CS and SASP in the SAMP6 mice.
These results suggest that lycopene may be beneficial for the management of senile osteoporosis by inhibiting oxidative stress, CS, and the SASP.
细胞衰老（CS）与包括骨骼衰老在内的组织衰老密切相关。CS和衰老相关分泌表型（SASP）已成为老年性骨质疏松症的关键发病机制要素。本研究旨在探讨番茄红素对老年性骨质疏松症的影响。
将衰老加速小鼠易感6（SAMP6）品系小鼠作为老年性骨质疏松症模型。SAMP6小鼠每日摄入番茄红素8周可维持骨量、骨密度、骨强度和骨微结构。此外，这些改变与老年性骨质疏松症模型中氧化应激的降低有关。此外，SAMP6小鼠骨组织中骨成细胞和骨细胞衰老以及SASP减少。番茄红素可能因其抗氧化特性改善骨骼健康，这可能与SAMP6小鼠中CS和SASP的调节有关。
这些结果表明，番茄红素可能通过抑制氧化应激、CS和SASP对老年性骨质疏松症的治疗有益。
